Emotion processing in Parkinson's disease: a blood oxygenation level-dependent functional magnetic resonance imaging study

被引:18
作者
Benzagmout, Mohammed [1 ,2 ,6 ]
Boujraf, Said [1 ,3 ,4 ]
Alami, Badreeddine [1 ,3 ,4 ]
Amadou, Hassane Ali [1 ,2 ]
El Hamdaoui, Halima [1 ,3 ]
Bennani, Amine [1 ]
Jaafari, Mounir [1 ,5 ]
Rammouz, Ismail [1 ,5 ]
Maaroufi, Mustapha [1 ,4 ]
Magoul, Rabia [6 ]
Boussaoud, Driss [1 ,7 ]
机构
[1] Fac Med, Lab Clin Neurosci, Fes, Morocco
[2] Univ Hosp Fez, Dept Neurosurg, Fes, Morocco
[3] Fac Med, Dept Biophys & Clin MRI Methods, Fes, Morocco
[4] Univ Hosp Fez, Dept Radiol & Clin Imaging, Fes, Morocco
[5] Univ Hosp Fez, Dept Psychiat, Fes, Morocco
[6] Fac Sci Dhar El Mahraz, Lab Neuroendocrinol & Nutr & Climat Environm, Fes, Morocco
[7] Aix Marseille Univ, INSERM, INS, Marseille, France
关键词
Parkinson's disease; emotion; processing; Blood oxygenation level-dependent functional magnetic resonance imaging; brain; activation; dopamine; neural regeneration; FACIAL EXPRESSION RECOGNITION; BRAIN PLASTICITY; POLYSULFONE MEMBRANE; PREFRONTAL CORTEX; METAANALYSIS; PERCEPTION; IMPAIRMENT; ACTIVATION; MATURATION; EXPERIENCE;
D O I
10.4103/1673-5374.247470
中图分类号
Q2 [细胞生物学];
学科分类号
071013 [干细胞生物学];
摘要
Parkinson's disease is a neurodegenerative disorder caused by loss of dopamine neurons in the substantia nigra pars compacta. Tremor, rigidity, and bradykinesia are the major symptoms of the disease. These motor impairments are often accompanied by affective and emotional dysfunctions which have been largely studied over the last decade. The aim of this study was to investigate emotional processing organization in the brain of patients with Parkinson's disease and to explore whether there are differences between recognition of different types of emotions in Parkinson's disease. We examined 18 patients with Parkinson's disease (8 men, 10 women) with no history of neurological or psychiatric comorbidities. All these patients underwent identical brain blood oxygenation level-dependent functional magnetic resonance imaging for emotion evaluation. Blood oxygenation level-dependent functional magnetic resonance imaging results revealed that the occipito-temporal cortices, insula, orbitofrontal cortex, basal ganglia, and parietal cortex which are involved in emotion processing, were activated during the functional control. Additionally, positive emotions activate larger volwnes of the same anatomical entities than neutral and negative emotions. Results also revealed that Parkinson's disease associated with emotional disorders are increasingly recognized as disabling as classic motor symptoms. These findings help clinical physicians to recognize the emotional dysfunction of patients with Parkinson's disease.
引用
收藏
页码:666 / 672
页数:7
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