Bisphosphonates: Mechanisms of action and clinical use in osteoporosis - An update

被引：53

作者：

Fleisch, H

机构：

来源：

HORMONE AND METABOLIC RESEARCH | 1997年 / 29卷 / 03期

关键词：

bisphosphonates; osteoporosis; bone;

D O I：

10.1055/s-2007-979008

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Bisphosphonates are a new class of compounds with the ability to decrease bone resorption. Their mode of action appears to be complex, involving both a direct effect on the osteoclasts and an indirect one through osteoblasts. They are currently the drugs of choice in humans for Paget's disease and tumor bone disease, and are most useful in various types of osteoporosis. In view of their low toxicity, they are a most valuable addition to our therapeutic possibilities in the treatment of bone diseases.

引用

页码：145 / 150

页数：6

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