GATA-1: One protein, many partners

被引：47

作者：

Lowry, JA ^{[1
]}

Mackay, JP ^{[1
]}

机构：

[1] Univ Sydney, Sch Mol & Microbial Biosci, Sydney, NSW 2006, Australia

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2006年 / 38卷 / 01期

关键词：

transcription; factor; zinc; finger; hematopoiesis;

D O I：

10.1016/j.biocel.2005.06.017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

GATA-1, the founding member of the GATA transcription factor family, is essential for cell maturation and differentiation within the erythroid and megakaryocytic lineages. GATA-1 regulates the expression of many genes within these lineages and its functionality depends upon its ability to bind both DNA and protein partners. Disruption of either of these functions causes severe hematopoietic dysfunction and results in blood disorders, such as thrombocytopenia and anemia. Within this review, we will focus on the structural aspects of GATA-1 with regard to interactions with its many partners and the identification of several mutations that disrupt these interactions. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：6 / 11

页数：6

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