Extracellular communication in bacteria

被引:64
作者
Chhabra, SR
Philipp, B
Eberl, L
Givskov, M
Williams, P
Cámara, M
机构
[1] Univ Nottingham, Inst Infect Immun & Inflammat, Ctr Biomol Sci, Nottingham NG7 2UH, England
[2] Tech Univ Denmark, Ctr Biomed Microbiol, Bioctr, DTU, DK-2800 Lyngby, Denmark
[3] Univ Zurich, Inst Plant Biol, Dept Microbiol, CH-8008 Zurich, Switzerland
[4] Univ Konstanz, Fac Biol Mikrobielle Okol, Fach M654, D-78457 Constance, Germany
[5] Univ Nottingham, Inst Infect Immun & Inflammat, Ctr Biomol Sci, Nottingham NG7 2RD, England
来源
CHEMISTRY OF PHEROMONES AND OTHER SEMIOCHEMICALS II | 2005年 / 240卷
关键词
quorum sensing; cell-cell signalling; N-acylhomoserine lactones; antibacterial agents; bacterial pheromones;
D O I
10.1007/b98319
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Populations of bacterial cells often coordinate their responses to changes in their local environmental conditions through "quorum sensing", a cell-to-cell communication system employing small diffusible signal molecules. While there is considerable diversity in the chemistry of such signal molecules, in different Gram-positive and Gram-negative bacteria they control pathogenicity, secondary metabolite production, biofilm differentiation, DNA transfer and bioluminescence. The development of biosensors for the detection of these signal molecules has greatly facilitated their subsequent chemical analysis which in turn has resulted in significant progress in understanding the molecular basis of quorum sensing-dependent gene expression. Consequently, the discovery and characterisation of natural molecules which antagonize quorum sensing-mediated responses has created new opportunities for the design of novel anti-infective agents which control infection through the attenuation of bacterial virulence.
引用
收藏
页码:279 / 315
页数:37
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