Mammalian microRNAs derived from genomic repeats

被引：217

作者：

Smalheiser, NR ^{[1
]}

Torvik, VI ^{[1
]}

机构：

[1] Univ Illinois, Inst Psychiat, Chicago, IL 60612 USA

来源：

TRENDS IN GENETICS | 2005年 / 21卷 / 06期

关键词：

D O I：

10.1016/j.tig.2005.04.008

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

In this article, we show that a subset of conventional mammalian microRNAs is derived from LINE-2 transposable elements and other genome repeats. These repeat-derived microRNAs arise from conventional precursor hairpins and are distinct from the rasiRNAs, which appear to be processed from long double-stranded RNA precursors. The insertion of transposable elements into new genomic sites appears to be one of the driving-forces that create new microRNAs during mammalian evolution. Two of the LINE-2-derived microRNAs exhibit perfect complementarity to a large family of mRNA and EST transcripts that contain portions of MIR and other LINE-2 elements in their 3'-untranslated regions.

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页码：322 / 326

页数：5

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