Embryonic stem cell-specific MicroRNAs

被引：960

作者：

Houbaviy, HB

Murray, MF

Sharp, PA

机构：

[1] MIT, Ctr Canc Res, Cambridge, MA 02139 USA

[2] MIT, McGovern Inst Brain Res, Cambridge, MA 02139 USA

[3] MIT, Dept Biol, Cambridge, MA 02139 USA

来源：

DEVELOPMENTAL CELL | 2003年 / 5卷 / 02期

关键词：

D O I：

10.1016/S1534-5807(03)00227-2

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We have identified microRNAs (miRNAs) in undifferentiated and differentiated mouse embryonic stem (ES) cells. Some of these appear to be ES cell specific, have related sequences, and are encoded by genomic loci clustered within 2.2 kb of each other. Their expression is repressed as ES cells differentiate into embryoid bodies and is undetectable in adult mouse organs. In contrast, the levels of many previously described miRNAs remain constant or increase upon differentiation. Our results suggest that miRNAs may have a role in the maintenance of the pluripotent cell state and in the regulation of early mammalian development.

引用

页码：351 / 358

页数：8

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