Notch pathway: Making sense of suppressor of hairless

被引:135
作者
Bray, S [1 ]
Furriols, M [1 ]
机构
[1] Univ Cambridge, Dept Anat, Cambridge CB2 3DY, England
关键词
D O I
10.1016/S0960-9822(01)00109-9
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Suppressor of Hairless (Su(H)) is a DNA-binding protein component of the Notch signalling pathway, thought to be required, with a fragment of the Notch receptor, for target gene activation. Recent studies show that this is only one side of the story: target gene enhancers may be regulated by Su(H) in a variety of different ways.
引用
收藏
页码:R217 / R221
页数:5
相关论文
共 28 条
[1]   SUPPRESSOR OF HAIRLESS DIRECTLY ACTIVATES TRANSCRIPTION OF ENHANCER OF SPLIT COMPLEX GENES IN RESPONSE TO NOTCH RECEPTOR ACTIVITY [J].
BAILEY, AM ;
POSAKONY, JW .
GENES & DEVELOPMENT, 1995, 9 (21) :2609-2622
[2]   A notch-independent activity of suppressor of hairless is required for normal mechanoreceptor physiology [J].
Barolo, S ;
Walker, RG ;
Polyanovsky, AD ;
Freschi, G ;
Keil, T ;
Posakony, JW .
CELL, 2000, 103 (06) :957-969
[3]   Spatially restricted factors cooperate with Notch in the regulation of Enhancer of split genes [J].
Cooper, MTD ;
Tyler, DM ;
Furriols, M ;
Chalkiadaki, A ;
Delidakis, C ;
Bray, S .
DEVELOPMENTAL BIOLOGY, 2000, 221 (02) :390-403
[4]   R7 photoreceptor specification requires Notch activity [J].
Cooper, MTD ;
Bray, SJ .
CURRENT BIOLOGY, 2000, 10 (23) :1507-1510
[5]   Combinatorial signaling in the specification of unique cell fates [J].
Flores, GV ;
Duan, H ;
Yan, HJ ;
Nagaraj, R ;
Fu, WM ;
Zou, Y ;
Noll, M ;
Banerjee, U .
CELL, 2000, 103 (01) :75-85
[6]   THE SUPPRESSOR OF HAIRLESS PROTEIN PARTICIPATES IN NOTCH RECEPTOR SIGNALING [J].
FORTINI, ME ;
ARTAVANISTSAKONAS, S .
CELL, 1994, 79 (02) :273-282
[7]   A model Notch response element detects Suppressor of Hairless-dependent molecular switch [J].
Furriols, M ;
Bray, S .
CURRENT BIOLOGY, 2001, 11 (01) :60-64
[8]   Dissecting the mechanisms of suppressor of hairless function [J].
Furriols, M ;
Bray, S .
DEVELOPMENTAL BIOLOGY, 2000, 227 (02) :520-532
[9]   MASKING OF THE CBF1/RBPJ(KAPPA) TRANSCRIPTIONAL REPRESSION DOMAIN BY EPSTEIN-BARR-VIRUS EBNA2 [J].
HSIEH, JJD ;
HAYWARD, SD .
SCIENCE, 1995, 268 (5210) :560-563
[10]   CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex [J].
Hsieh, JJD ;
Zhou, SF ;
Chen, L ;
Young, DB ;
Hayward, SD .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (01) :23-28