共 47 条
Characterization of a canine homolog of hepatitis C virus
被引:206
作者:
Kapoor, Amit
[1
]
Simmonds, Peter
[2
]
Gerold, Gisa
[3
]
Qaisar, Natasha
[1
]
Jain, Komal
[1
]
Henriquez, Jose A.
[1
]
Firth, Cadhla
[1
]
Hirschberg, David L.
[1
]
Rice, Charles M.
[3
]
Shields, Shelly
[4
]
Lipkin, W. Ian
[1
]
机构:
[1] Columbia Univ, Ctr Infect & Immun, New York, NY 10032 USA
[2] Univ Edinburgh, Ashworth Labs, Ctr Immunol Infect & Evolut, Edinburgh EH9 3JT, Midlothian, Scotland
[3] Rockefeller Univ, Lab Virol & Infect Dis, Ctr Study Hepatitis C, New York, NY USA
[4] Pfizer Vet Med Res & Dev, New York, NY 10017 USA
来源:
基金:
美国国家卫生研究院;
关键词:
flavivirus;
zoonosis;
CDNA-CLONE;
GENOME;
IDENTIFICATION;
TRANSMISSION;
REPLICATION;
TRANSLATION;
EVOLUTION;
INFECTION;
REVEALS;
HISTORY;
D O I:
10.1073/pnas.1101794108
中图分类号:
O [数理科学和化学];
P [天文学、地球科学];
Q [生物科学];
N [自然科学总论];
学科分类号:
07 ;
0710 ;
09 ;
摘要:
An estimated 3% of the world's population is chronically infected with hepatitis C virus (HCV). Although HCV was discovered more than 20 y ago, its origin remains obscure largely because no closely related animal virus homolog has been identified; furthermore, efforts to understand HCV pathogenesis have been hampered by the absence of animal models other than chimpanzees for human disease. Here we report the identification in domestic dogs of a nonprimate hepacivirus. Comparative phylogenetic analysis of the canine hepacivirus (CHV) confirmed it to be the most genetically similar animal virus homolog of HCV. Bayesian Markov chains Monte Carlo and associated time to most recent common ancestor analyses suggest a mean recent divergence time of CHV and HCV clades within the past 500-1,000 y, well after the domestication of canines. The discovery of CHV may provide new insights into the origin and evolution of HCV and a tractable model system with which to probe the pathogenesis, prevention, and treatment of diseases caused by hepacivirus infection.
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页码:11608 / 11613
页数:6
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