Phytochemical and Pharmacological Profile of Vitex negundo

被引：47

作者：

Zheng, Cheng-Jian ^{[1
,2
]}

Li, Hua-Qiang ^{[2
]}

Ren, Shan-Cheng ^{[1
]}

Xu, Chuan-Liang ^{[1
]}

Rahman, Khalid ^{[3
]}

Qin, Lu-Ping ^{[2
]}

Sun, Ying-Hao ^{[1
]}

机构：

[1] Second Mil Med Univ, Shanghai Changhai Hosp, Dept Urol, Shanghai 200433, Peoples R China

[2] Second Mil Med Univ, Sch Pharm, Dept Pharmacognosy, Shanghai 200433, Peoples R China

[3] Liverpool John Moores Univ, Sch Biomol Sci, Fac Sci, Liverpool L3 3AF, Merseyside, England

来源：

PHYTOTHERAPY RESEARCH | 2015年 / 29卷 / 05期

基金：

中国国家自然科学基金;

关键词：

Vitex negundo; Verbenaceae; chemistry; pharmacology; INDIAN MEDICINAL-PLANTS; INDUCED DIABETIC-RATS; ANTIINFLAMMATORY ACTIVITY; LEAF EXTRACT; IN-VITRO; CULEX-TRITAENIORHYNCHUS; ANTIOXIDANT PROPERTIES; REPELLENT ACTIVITY; IRIDOID GLUCOSIDE; OXIDATIVE STRESS;

D O I：

10.1002/ptr.5303

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The article aims to review all the chemical constituents and pharmacological properties of Vitex negundo L. (Verbenaceae) (VN). VN is an important medicinal plant used as reputed herbal medicine with versatile pharmacological activities in China, India and Japan. A total of 104 referred articles about VN were compiled from major databases and academic publishers, such as MEDLINE, Pubmed, Scholar, Elsevier, Springer, Wiley and CNKI. As a result, a total of 120 compounds isolated from VN can be divided mainly into four classes: flavonoids, lignans, terpenoids and steroids. The crude extracts and purified compounds of VN exhibited promising bioactivities, including anti-nociceptive, antiinflammatory, anti-tumor, anti-oxidant, insecticidal, antimicrobial, anti-androgenic, anti-osteoporotic, anti-cataract, hepatoprotective and anti-hyperglycemic activity. All the reported data lead us to conclude that VN has convincing medicinal potential. However, further researches are needed to explore its bioactive constituents, the structure-activity relationship and their molecular mechanisms of action. Copyright (c) 2015 John Wiley & Sons, Ltd.

引用

页码：633 / 647

页数：15

共 105 条

[11] ANTIANDROGENIC EFFECTS OF A FLAVONOID-RICH FRACTION OF VITEX-NEGUNDO SEEDS - A HISTOLOGICAL AND BIOCHEMICAL-STUDY IN DOGS
BHARGAVA, SK
[J]. JOURNAL OF ETHNOPHARMACOLOGY, 1989, 27 (03) : 327 - 339
[12] Cais YL, 2008, J HUNAN NORMAL U, V5, P24
[13] Isolation, characterization and biological activity of betulinic acid and ursolic acid from Vitex negundo L.
Chandramu, C
Manohar, RD
Krupadanam, DGL
Dashavantha, RV
[J]. PHYTOTHERAPY RESEARCH, 2003, 17 (02) : 129 - 134
[14] CHEMICAL INVESTIGATION AND ANTIINFLAMMATORY ACTIVITY OF VITEX-NEGUNDO SEEDS
CHAWLA, AS
SHARMA, AK
HANDA, SS
[J]. JOURNAL OF NATURAL PRODUCTS, 1992, 55 (02): : 163 - 167
[15] CHAWLA AS, 1991, INDIAN J CHEM B, V30, P773
[16] A LIGNAN FROM VITEX-NEGUNDO SEEDS
CHAWLA, AS
SHARMA, AK
HANDA, SS
DHAR, KL
[J]. PHYTOCHEMISTRY, 1992, 31 (12) : 4378 - 4379
[17] Insecticidal activity of compounds from the leaves of Vitex negundo (Verbenaceae) against Tribolium castaneum (Coleoptera: Tenebrionidae)
Chowdhury N.Y.
Islam W.
Khalequzzaman M.
[J]. International Journal of Tropical Insect Science, 2011, 31 (3) : 174 - 181
[18] Chowdhury N.Y., 2010, J BIO-SCI, V18, P53
[19] Reproduction in male rats is vulnerable to treatment with the flavonoid-rich seed extracts of Vitex negundo
Das, S
Parveen, S
Kundra, CP
Pereira, BMJ
[J]. PHYTOTHERAPY RESEARCH, 2004, 18 (01) : 8 - 13
[20] Davids BV, 1988, INSECTIC, V22, P27

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