The VIZIER project:: Preparedness against pathogenic RNA viruses

被引：17

作者：

Coutard, B. ^{[1
,2
,29
]}

Gorbalenya, A. E. ^{[4
]}

Snijder, E. J. ^{[4
]}

Leontovich, A. M. ^{[27
]}

Poupon, A. ^{[3
]}

De lamballerie, X. ^{[5
]}

Charrel, R. ^{[5
]}

Gould, E. A. ^{[6
]}

Gunther, S. ^{[10
]}

Norder, H. ^{[7
]}

Klempa, B. ^{[8
]}

Bourhy, H. ^{[9
]}

Rohayem, J. ^{[11
]}

L'hermite, E. ^{[12
]}

Nordlund, P. ^{[28
]}

Stuart, D. I. ^{[13
]}

Owens, R. J. ^{[13
]}

Grimes, J. M. ^{[13
]}

Tucker, P. A. ^{[14
]}

Bolognesi, M. ^{[15
]}

Mattevi, A. ^{[16
]}

Coll, M. ^{[17
,18
]}

Jones, T. A. ^{[20
]}

Aqvist, J. ^{[20
]}

Unge, T. ^{[20
]}

Hilgenfeld, R. ^{[21
]}

Bricogne, G. ^{[19
]}

Neyts, J. ^{[22
]}

La Colla, P. ^{[23
]}

Puerstinger, G. ^{[26
]}

Gonzalez, J. P. ^{[24
,25
]}

Leroy, E. ^{[24
,25
]}

Cambillau, C. ^{[1
,2
,29
]}

Romette, J. L. ^{[1
,2
,29
]}

Canard, B. ^{[1
,2
,29
]}

机构：

[1] CNRS, Architecture & Fonct Macromol Biol, F-13288 Marseille 09, France

[2] Univ Aix Marseille 1, UMR 6098, F-13288 Marseille 09, France

[3] Univ Paris 11, CNRS UMR 8619, IBBMC, Struct Genom Lab,IFR 115, Orsay, France

[4] Leiden Univ, Med Ctr, Ctr Infect Dis, Dept Med Microbiol,Mol Virol Lab, NL-2300 RC Leiden, Netherlands

[5] Fac Med, Unite Virus Emergents, EA3292,IFR48, IRD UR034, F-13005 Marseille, France

[6] Ctr Ecol & Hydrol Oxford, Oxford OX1 3SR, England

[7] Swedish Inst Infect Dis Control, VIV, Sect Hepatitis & Enteroviruses, SE-17182 Solna, Sweden

[8] Slovak Acad Sci, Inst Virol, Bratislava 84505, Slovakia

[9] Inst Pasteur, Lab Rage, F-75724 Paris 15, France

[10] Bernhard Nocht Inst Trop Med, D-20359 Hamburg, Germany

[11] Med Fak Carl Gustav Carus, Inst Virol, Calicilab, D-01307 Dresden, Germany

[12] BioXtal, CH-1066 Epalinges, Switzerland

[13] Univ Oxford, Oxford Protein Prod Facil, Oxford OX3 7BN, England

[14] DESY, European Mol Biol Lab, D-22603 Hamburg, Germany

[15] Univ Milan, CNR, INFM, Dept Biomol Sci & Biotechnol, I-20133 Milan, Italy

[16] Univ Pavia, Dept Genet & Microbiol, I-27100 Pavia, Italy

[17] CSIC, Inst Recerca Biomedia, E-08028 Barcelona, Spain

[18] CSIC, Inst Mol Biol, E-08028 Barcelona, Spain

[19] Sheraton House, Global Phasing, Cambridge CB3 0AX, England

[20] Uppsala Univ, Biomed Ctr, Dept Cell & Mol Biol, SE-75124 Uppsala, Sweden

[21] Med Univ Lubeck, Ctr Struct & Cell Biol Med, Inst Biochem, D-23538 Lubeck, Germany

[22] Rega Inst, B-3000 Louvain, Belgium

[23] Univ Cagliari, Dept Sci & Biomed Technol, I-09142 Cagliari, Italy

[24] Mahidol Univ, IRD R178, Nakhon Pathom 73170, Thailand

[25] CIRMF, IRD R178, Franceville, Gabon

[26] Univ Innsbruck, Abt Pharmazeut Chem, Inst Pharm, A-6020 Innsbruck, Austria

[27] Moscow MV Lomonosov State Univ, Belozersky Inst Phys Chem Biol, Moscow 119899, Russia

[28] Stockholm Univ, Dept Biochem & Biophys, S-10691 Stockholm, Sweden

[29] Univ Aix Marseille 2, UMR 6098, F-13288 Marseille 09, France

来源：

ANTIVIRAL RESEARCH | 2008年 / 78卷 / 01期

基金：

英国医学研究理事会; 英国自然环境研究理事会;

关键词：

RNA virus; genomics; crystal structure; replicase; antivirals; drug-design;

D O I：

10.1016/j.antiviral.2007.10.013

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Life-threatening RNA viruses emerge regularly, and often in an unpredictable manner. Yet, the very few drugs available against known RNA viruses have sometimes required decades of research for development. Can we generate preparedness for outbreaks of the, as yet, unknown viruses? The VIZIER (VIral enZymes InvolvEd in Replication) (http://www.vizier-europe.org/) project has been set-up to develop the scientific foundations for countering this challenge to society. VIZIER studies the most conserved viral enzymes (that of the replication machinery, or replicases) that constitute attractive targets for drug-design. The aim of VIZIER is to determine as many replicase crystal structures as possible from a carefully selected list of viruses in order to comprehensively cover the diversity of the RNA virus universe, and generate critical knowledge that could be efficiently utilized to jump-start research on any emerging RNA virus. VIZIER is a multidisciplinary project involving (i) bioinformatics to define functional domains, (ii) viral genomics to increase the number of characterized viral genomes and prepare defined targets, (iii) proteomics to express, purify, and characterize targets, (iv) structural biology to solve their crystal structures, and (v) pre-lead discovery to propose active scaffolds of antiviral molecules. (C) 2007 Elsevier B.V. All rights reserved.

引用

页码：37 / 46

页数：10

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