Lipid distribution and transport across cellular membranes

被引：126

作者：

Pomorski, T

Hrafnsdóttir, S

Devaux, PF

van Meer, G

机构：

[1] Univ Amsterdam, Acad Med Ctr, Dept Cell Biol & Histol, NL-1100 DE Amsterdam, Netherlands

[2] Inst Biol Physicochim, F-75005 Paris, France

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2001年 / 12卷 / 02期

关键词：

flipflop; lipid asymmetry; translocase; flippases; ABC transporter;

D O I：

10.1006/scdb.2000.0231

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In eukaryotic cells, the membranes of different intracellular organelles have differ ent lipid composition, and various biomembranes show an asymmetric distribution of lipid types across the membrane bilayer Membrane lipid organization reflects a dynamic equilibrium of lipids moving across the bilayer in both directions. In this review, we summarize data supporting the role of specific membrane proteins in catalyzing transbilayer lipid movement, thereby controlling and regulating the distribution of lipids over the leaflets of biomembranes.

引用

收藏

页码：139 / 148

页数：10

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