Parathyroid hormone protects against periodontitis-associated bone loss

被引：75

作者：

Barros, SP

Silva, MAD

Somerman, MJ

Nociti, FH

机构：

[1] Univ Campinas, Dept Morphol, Div Histol, Sch Dent Piracicaba, BR-13414903 Piracicaba, SP, Brazil

[2] Univ Washington, Dept Periodont, Sch Dent, Seattle, WA 98195 USA

[3] Univ Michigan, Dept Periodont Prevent Geriatr, Sch Dent, Ann Arbor, MI 48109 USA

[4] Univ Campinas, Dept Prosthodont Periodont, Div Periodont, Sch Dent Piracicaba, Campinas, Brazil

来源：

JOURNAL OF DENTAL RESEARCH | 2003年 / 82卷 / 10期

关键词：

parathyroid hormone; periodontitis; anabolism;

D O I：

10.1177/154405910308201006

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Parathyroid hormone (PTH) functions as a major mediator of bone remodeling and as an essential regulator of calcium homeostasis. In addition to the well-established catabolic effects (activation of bone resorption) of PTH, it is now recognized that intermittent PTH administration has anabolic effects (promotion of bone formation). The aim of this study was to investigate whether intermittent administration of PTH in rodents would block the alveolar bone loss observed in rats when a ligature model of periodontitis is used. Morphometric analysis showed that intermittent PTH administration (40 mug/kg) was able to protect the tooth site from periodontitis-induced bone resorption. In addition, there was a significant reduction in the number of inflammatory cells at the marginal gingival area in sections obtained from animals receiving PTH compared with control animals. These findings demonstrated that intermittent PTH administration was able to protect against periodontitis-associated bone loss in a rodent model.

引用

页码：791 / 795

页数：5