Presenting vancomycin on nanoparticles to enhance antimicrobial activities

被引：490

作者：

Gu, HW

Ho, PL

Tong, E

Wang, L

Xu, B ^{[1
]}

机构：

[1] Hong Kong Univ Sci & Technol, Dept Chem, Hong Kong, Peoples R China

[2] Univ Hong Kong, Fac Med, Ctr Infect, Hong Kong, Peoples R China

[3] Univ Hong Kong, Fac Med, Dept Microbiol, Hong Kong, Peoples R China

来源：

NANO LETTERS | 2003年 / 3卷 / 09期

关键词：

D O I：

10.1021/nl034396z

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Here we report the synthesis of vancomycin (Van)-capped Au nanoparticles (Au@Van) and their enhanced in vitro antibacterial activities. Au@Van presumably acts as a rigid polyvalent inhibitor of vancomycin-resistant enterococci (VRE). It also has unexpected activity against an E. coli strain. Our results suggest that gold nanoparticles may serve as a useful model system to explore multi/polyvalent interactions of ligand-receptor pairs.

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页码：1261 / 1263

页数：3

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