CD11b and CD27 reflect distinct population and functional specialization in human natural killer cells

被引：165

作者：

Fu, Binqing ^{[1
,2
]}

Wang, Fuyan ^{[1
,2
]}

Sun, Rui ^{[1
,2
]}

Ling, Bin ^{[3
]}

Tian, Zhigang ^{[1
,2
]}

Wei, Haiming ^{[1
,2
]}

机构：

[1] Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei 230027, Anhui, Peoples R China

[2] Univ Sci & Technol China, Sch Life Sci, Hefei 230027, Anhui, Peoples R China

[3] Anhui Prov Hosp, Hefei, Anhui, Peoples R China

来源：

IMMUNOLOGY | 2011年 / 133卷 / 03期

关键词：

cell development; cellular immunology; decidual natural killer cells; human natural killer cells; innate immunity; SECONDARY LYMPHOID-TISSUE; NK-CELLS; DENDRITIC CELLS; BONE-MARROW; SUBSETS; TRANSPLANTATION; EXPRESSION; DIFFERENTIATION; CYTOTOXICITY; PROGENITORS;

D O I：

10.1111/j.1365-2567.2011.03446.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

P>The identification of developmental stages in natural killer (NK) cells, especially in human NK cells, has lagged for decades. We characterize four novel populations defined by CD11b and CD27, which can represent the distinct stages of human NK cells from different tissues. Nearly all NK cells from peripheral blood are CD11b+ CD27- populations whereas NK cells from cord blood have CD11b+ CD27- and CD11b+ CD27+ populations. Interestingly, we have found large CD11b- CD27- populations of NK cells from deciduas. We also demonstrate that each population could be characterized by unique functional and phenotypic attributes. CD11b- CD27- NK cells display an immature phenotype and potential for differentiation. CD11b- CD27+ and CD11b+ CD27+ NK cells show the best ability to secrete cytokines. CD11b+ CD27- NK cells exhibit high cytolytic function. We demonstrate that human NK cells at different developmental stages have special functions and describe a new model of human NK cell differentiation.

引用

页码：350 / 359

页数：10

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