共 42 条
Identification of an innate T helper type 17 response to intestinal bacterial pathogens
被引:196
作者:

Geddes, Kaoru
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Toronto, Dept Immunol, Toronto, ON, Canada Univ Toronto, Dept Immunol, Toronto, ON, Canada

Rubino, Stephen J.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada Univ Toronto, Dept Immunol, Toronto, ON, Canada

论文数: 引用数:
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Streutker, Catherine
论文数: 0 引用数: 0
h-index: 0
机构:
St Michaels Hosp, Dept Lab Med, Toronto, ON M5B 1W8, Canada Univ Toronto, Dept Immunol, Toronto, ON, Canada

Le Bourhis, Lionel
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Toronto, Dept Immunol, Toronto, ON, Canada Univ Toronto, Dept Immunol, Toronto, ON, Canada

Cho, Joon Ho
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h-index: 0
机构:
Univ Toronto, Dept Immunol, Toronto, ON, Canada Univ Toronto, Dept Immunol, Toronto, ON, Canada

Robertson, Susan J.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Toronto, Dept Immunol, Toronto, ON, Canada Univ Toronto, Dept Immunol, Toronto, ON, Canada

Kim, Connie J.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Toronto, Dept Med, Toronto, ON, Canada Univ Toronto, Dept Immunol, Toronto, ON, Canada

Kaul, Rupert
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Toronto, Dept Immunol, Toronto, ON, Canada
Univ Toronto, Dept Med, Toronto, ON, Canada Univ Toronto, Dept Immunol, Toronto, ON, Canada

Philpott, Dana J.
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h-index: 0
机构:
Univ Toronto, Dept Immunol, Toronto, ON, Canada Univ Toronto, Dept Immunol, Toronto, ON, Canada

Girardin, Stephen E.
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h-index: 0
机构:
Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada Univ Toronto, Dept Immunol, Toronto, ON, Canada
机构:
[1] Univ Toronto, Dept Immunol, Toronto, ON, Canada
[2] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada
[3] St Michaels Hosp, Dept Lab Med, Toronto, ON M5B 1W8, Canada
[4] Univ Toronto, Dept Med, Toronto, ON, Canada
基金:
加拿大健康研究院;
关键词:
ENTERICA SEROTYPE TYPHIMURIUM;
INDUCER-LIKE CELLS;
HOST-DEFENSE;
DENDRITIC CELLS;
IL-17;
DIFFERENTIATION;
INTERLEUKIN-17;
INFECTION;
EXPRESSION;
T(H)17;
D O I:
10.1038/nm.2391
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
Interleukin 17 (IL-17) is a central cytokine implicated in inflammation and antimicrobial defense. After infection, both innate and adaptive IL-17 responses have been reported, but the type of cells involved in innate IL-17 induction, as well as their contribution to in vivo responses, are poorly understood. Here we found that Citrobacter and Salmonella infection triggered early IL-17 production, which was crucial for host defense and was mediated by CD4(+) T helper cells. Enteric innate T helper type 17 (iT(H)17) responses occurred principally in the cecum, were dependent on the Nod-like receptors Nod1 and Nod2, required IL-6 induction and were associated with a decrease in mucosal CD103(+) dendritic cells. Moreover, imprinting by the intestinal microbiota was fully required for the generation of iT(H)17 responses. Together, these results identify the Nod-iT(H)17 axis as a central element in controlling enteric pathogens, which may implicate Nod-driven iT(H)17 responses in the development of inflammatory bowel diseases.
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页码:837 / U202
页数:9
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Univ Brescia, Dept Pathol 1, Spedali Civili, I-25123 Brescia, Italy Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA

Otero, Karel
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Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA

Lennerz, Jochen K. M.
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Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA

Doherty, Jason M.
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Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA

Mills, Jason C.
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Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA

Colonna, Marco
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Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA
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Cho, Judy H.
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Yale Univ, Ctr Inflammatory Bowel Dis, Sect Digest Dis, New Haven, CT 06520 USA Yale Univ, Ctr Inflammatory Bowel Dis, Sect Digest Dis, New Haven, CT 06520 USA
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Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA