A role for dystroglycan in basement membrane assembly

被引:332
作者
Henry, MD
Campbell, KP [1 ]
机构
[1] Univ Iowa, Coll Med, Howard Hughes Med Inst, Dept Physiol & Biophys, Iowa City, IA 52242 USA
[2] Univ Iowa, Coll Med, Howard Hughes Med Inst, Dept Neurol, Iowa City, IA 52242 USA
关键词
D O I
10.1016/S0092-8674(00)81708-0
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Basement membranes are composed of ordered arrays of characteristic extracellular matrix proteins, but little is known about the assembly of these structures in vivo. We have investigated the function of dystroglycan, a cell-surface laminin receptor expressed by cells contacting basement membranes in developing and adult tissues. We find that dystroglycan is required for the formation of a basement membrane in embryoid bodies. Our results further indicate that dystroglycan-laminin interactions are prerequisite for the deposition of other basement membrane proteins. Dystroglycan may exert its influence on basement membrane assembly by binding soluble laminin and organizing it on the cell surface. These data establish a role for dystroglycan in the assembly of basement membranes and suggest fundamental mechanisms underlying this process.
引用
收藏
页码:859 / 870
页数:12
相关论文
共 54 条
  • [1] BASEMENT-MEMBRANE HEPARAN-SULFATE PROTEOGLYCAN BINDS TO LAMININ BY ITS HEPARAN-SULFATE CHAINS AND TO NIDOGEN BY SITES IN THE PROTEIN CORE
    BATTAGLIA, C
    MAYER, U
    AUMAILLEY, M
    TIMPL, R
    [J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1992, 208 (02): : 359 - 366
  • [2] beta 1 integrin is essential for teratoma growth and angiogenesis
    Bloch, W
    Forsberg, E
    Lentini, S
    Brakebusch, C
    Martin, K
    Krell, HW
    Weidle, UH
    Addicks, K
    Fassler, R
    [J]. JOURNAL OF CELL BIOLOGY, 1997, 139 (01) : 265 - 278
  • [3] ROLE FOR DYSTROPHIN-ASSOCIATED GLYCOPROTEINS AND UTROPHIN IN AGRIN-INDUCED ACHR CLUSTERING
    CAMPANELLI, JT
    ROBERDS, SL
    CAMPBELL, KP
    SCHELLER, RH
    [J]. CELL, 1994, 77 (05) : 663 - 674
  • [4] Self-assembly of laminin isoforms
    Cheng, YS
    Champliaud, MF
    Burgeson, RE
    Marinkovich, MP
    Yurchenco, PD
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (50) : 31525 - 31532
  • [5] Laminin-induced clustering of dystroglycan on embryonic muscle cells: Comparison with agrin-induced clustering
    Cohen, MW
    Jacobson, C
    Yurchenco, PD
    Morris, GE
    Carbonetto, S
    [J]. JOURNAL OF CELL BIOLOGY, 1997, 136 (05) : 1047 - 1058
  • [6] SYNTHESIS AND DISTRIBUTION OF LAMININ-RELATED POLYPEPTIDES IN EARLY AMPHIBIAN EMBRYOS
    DARRIBERE, T
    RIOU, JF
    LISHI, D
    DELARUE, M
    BOUCAUT, JC
    [J]. CELL AND TISSUE RESEARCH, 1986, 246 (01) : 45 - 51
  • [7] EXPRESSION OF ESCHERICHIA-COLI BETA-GALACTOSIDASE AND RAT HPRT IN THE CNS OF MACACA-MULATTA FOLLOWING ADENOVIRAL MEDIATED GENE-TRANSFER
    DAVIDSON, BL
    DORAN, SE
    SHEWACH, DS
    LATTA, JM
    HARTMAN, JW
    ROESSLER, BJ
    [J]. EXPERIMENTAL NEUROLOGY, 1994, 125 (02) : 258 - 267
  • [8] Inhibition of laminin alpha 1-chain expression leads to alteration of basement membrane assembly and cell differentiation
    De Arcangelis, A
    Neuville, P
    Boukamel, R
    Lefebvre, O
    Kedinger, M
    SimonAssmann, P
    [J]. JOURNAL OF CELL BIOLOGY, 1996, 133 (02) : 417 - 430
  • [9] The receptor tyrosine kinase MuSK is required for neuromuscular junction formation in vivo
    DeChiara, TM
    Bowen, DC
    Valenzuela, DM
    Simmons, MV
    Poueymirou, WT
    Thomas, S
    Kinetz, E
    Compton, DL
    Rojas, E
    Park, JS
    Smith, C
    DiStefano, PS
    Glass, DJ
    Burden, SJ
    Yancopoulos, GD
    [J]. CELL, 1996, 85 (04) : 501 - 512
  • [10] alpha 3 beta 1 integrin is required for normal development of the epidermal basement membrane
    DiPersio, CM
    HodivalaDilke, KM
    Jaenisch, R
    Kreidberg, JA
    Hynes, RO
    [J]. JOURNAL OF CELL BIOLOGY, 1997, 137 (03) : 729 - 742