Differences in sensitivity to the aversive effects of ethanol in low-alcohol drinking (UChA) and high-alcohol drinking (UChB) rats

被引：28

作者：

Quintanilla, ME ^{[1
]}

Callejas, O ^{[1
]}

Tampier, L ^{[1
]}

机构：

[1] Univ Chile, Fac Med, ICBM, Program Mol & Clin Pharmacol, Santiago 7, Chile

来源：

ALCOHOL | 2001年 / 23卷 / 03期

关键词：

conditioned taste aversion; oral alcohol preference; alcohol aversion;

D O I：

10.1016/S0741-8329(01)00128-8

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

A conditioned taste aversion paradigm was used to determine whether aversion to the pharmacological effects of ethanol, apart from orosensory cues, can contribute to differences in voluntary ethanol consumption in rats of the low-alcohol drinking (UChA) and the high-alcohol drinking (UChB) strains. "Alcohol-naive" UChA and UChB rats were injected intraperitoneally with ethanol (0.5, 1.0, 1.5, or 2.0 g/kg) or saline, paired with consumption of a banana-flavored solution during five conditioning trials. Repeated pairings of banana-flavored solution and ethanol at a dose of 1.5 g/kg produced aversion to the banana-flavored solution in UChA rats, but not in UChB rats, at comparable blood ethanol levels. In addition, the highest dose of ethanol tested (2.0 g/kg) produced stronger aversion to the banana-flavored solution in UChA rats, compared with findings in UChB rats. From these results it is suggested that rats of the UChA strain find the postingestional effects of high-dose ethanol more aversive than do UChB rats. Differences in voluntary ethanol consumption seem to be associated with differences in sensitivity to the aversive effects of ethanol. (C) 2001 Elsevier Science Inc. All rights reserved.

引用

页码：177 / 182

页数：6

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