Focal adhesions: structure and dynamics

被引：275

作者：

Petit, V ^{[1
]}

Thiery, JP ^{[1
]}

机构：

[1] Inst Curie, CNRS, UMR 144, Div Res, F-75248 Paris 05, France

来源：

BIOLOGY OF THE CELL | 2000年 / 92卷 / 07期

关键词：

focal adhesion; integrins; extracellular matrix; Rho;

D O I：

10.1016/S0248-4900(00)01101-1

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Interactions of cells with the extracellular matrix are essential for the control of tissue remodelling, cell migration, and embryogenesis. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where transmembrane adhesion receptors provide a structural link between the actin cytoskeleton and the extracellular matrix components. Numerous structural and regulatory proteins assemble at the cytoplasmic face of focal adhesions in a Rho-dependent fashion. (C) 2000 Editions scientifiques et medicales Elsevier SAS.

引用

页码：477 / 494

页数：18

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