Melatonin treatment for circadian rhythm sleep disorders

被引:25
作者
Okawa, M
Uchiyama, M
Ozaki, S
Shibui, K
Kamei, Y
Hayakawa, T
Urata, J
机构
[1] Natl Ctr Neurol & Psychiat, National Institute Mental Health, Dept Psychophysiol, Chiba 272, Japan
[2] Natl Ctr Neurol & Psychiat, Kohnodai Hosp, Dept Neuropsychiat, Chiba, Japan
关键词
actigraph; body temperature; delayed sleep phase syndrome; melatonin; non-24-hour sleep-wake syndrome; sleep log;
D O I
10.1111/j.1440-1819.1998.tb01063.x
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
We administered 1-3 mg melatonin to 11 patients (eight men, three women, aged 16-46 years) with circadian rhythm sleep disorders; nine with delayed sleep phase syndrome and two with non-24-hour sleep-wake syndrome. Sleep logs were recorded throughout the study periods and actigraph and rectal temperature were monitored during treatment periods. Melatonin was administered 1-2 h before the desirable bedtime for expected phase-shifting, or 0.5-1 h before habitual bedtime for gradual advance expecting an hypnotic effect of the melatonin. Melatonin treatments were successful in 6/11 patients. Timing and dose of melatonin administration, together with its pharmacological properties for circadian rhythm sleep disorders, should be further studied.
引用
收藏
页码:259 / 260
页数:2
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