Cheilanthane sesterterpenes, protein kinase inhibitors, from a marine sponge of the genus Ircinia

被引：40

作者：

Buchanan, MS ^{[1
]}

Edser, A ^{[1
]}

King, G ^{[1
]}

Whitmore, J ^{[1
]}

Quinn, RJ ^{[1
]}

机构：

[1] Griffith Univ, AstraZeneca R&D, Brisbane, Qld 4111, Australia

来源：

JOURNAL OF NATURAL PRODUCTS | 2001年 / 64卷 / 03期

关键词：

D O I：

10.1021/np0004597

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Four cheilanthane sesterterpenoids, 25-hydroxy-13(24), 15, 17-cheilanthatrien- 19,25-olide (1), 13,16-epoxya5-hydroxy- 17-cheilanthen- 19,25-olide (2), 25-hydroxy-13(24), 17-cheilanthadien-16,19-olide (3), and 16,25-dihydroxy-13(24),17-cheilanthadien 19,25-olide (4), were isolated from the marine sponge Ircinia sp. Compounds 1, 3, and 4 are new natural products. The four compounds inhibit MSK1 (mitogen and stress activated kinase) and MAPKAPK-2 (mitogen activated protein kinase activated protein kinase), two protein kinases involved in mitogen and stress signal transduction.

引用

页码：300 / 303

页数：4

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