Unaffected family members and schizophrenia patients share brain structure patterns: A high-dimensional pattern classification study

被引:99
作者
Fan, Yong [1 ]
Gur, Raquel E. [2 ]
Gur, Ruben C. [2 ]
Wu, Xiaoying [1 ]
Shen, Dinggang [1 ]
Calkins, Monica E. [2 ]
Davatzikos, Christos [1 ]
机构
[1] Univ Penn, Sch Med, Dept Radiol, Sect Biomed Image Anal, Philadelphia, PA 19104 USA
[2] Univ Penn, Sch Med, Dept Psychiat, Brain & Behav Lab, Philadelphia, PA 19104 USA
关键词
classification; high-dimensional pattern; schizophrenia; structural MRI; unaffected family member;
D O I
10.1016/j.biopsych.2007.03.015
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Background: A number of studies have provided evidence for genetic modulation of brain structure in unaffected family members (FM) of schizophrenia patients using conventional volumetric analysis. High-dimensional pattern classification methods have been reported to have the capacity to determine subtle and spatially complex structural patterns that distinguish schizophrenia patients from healthy control subjects using standard magnetic resonance imaging. This study investigates whether such enclophenotypic patterns are found in FM via similar image analysis approaches. Methods: A high-dimensional pattern classifier was constructed from a group of 69 patients and 79 control subjects, via an analysis that identified a subtle and spatially complex pattern of reduced brain volumes. The constructed classifier was applied to examine brain structure of 30 FM. Results: The classifier indicated that FM had highly overlapping structural profiles with those of patients. Moreover, an orbitofrontal region of relatively increased white matter was found to contribute significantly to the classification, indicating that white matter alterations, along with reductions of gray matter volumes, might be present in patients and unaffected FM. Conclusions: These findings provide evidence that high-dimensional pattern classification can identify complex and subtle structural endophenotypes that are shared by probands and their unaffected FM.
引用
收藏
页码:118 / 124
页数:7
相关论文
共 28 条
[11]   An image-processing system for qualitative and quantitative volumetric analysis of brain images [J].
Goldszal, AF ;
Davatzikos, C ;
Pham, DL ;
Yan, MXH ;
Bryan, RN ;
Resnick, SM .
JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 1998, 22 (05) :827-837
[12]   Temporolimbic volume reductions in schizophrenia [J].
Gur, RE ;
Turetsky, BI ;
Cowell, PE ;
Finkelman, C ;
Maany, V ;
Grossman, RI ;
Arnold, SE ;
Bilker, WB ;
Gur, RC .
ARCHIVES OF GENERAL PSYCHIATRY, 2000, 57 (08) :769-775
[13]  
GUR RE, 1991, AM J PSYCHIAT, V148, P472
[14]   Subcortical MRI volumes in neuroleptic-naive and treated patients with schizophrenia [J].
Gur, RE ;
Maany, V ;
Mozley, D ;
Swanson, C ;
Bilker, W ;
Gur, RC .
AMERICAN JOURNAL OF PSYCHIATRY, 1998, 155 (12) :1711-1717
[15]   Reduced dorsal and orbital prefrontal gray matter volumes in schizophrenia [J].
Gur, RE ;
Cowell, PE ;
Latshaw, A ;
Turetsky, BI ;
Grossman, RI ;
Arnold, SE ;
Bilker, WB ;
Gur, RC .
ARCHIVES OF GENERAL PSYCHIATRY, 2000, 57 (08) :761-768
[16]   Magnetic resonance imaging and spectroscopy in offspring at risk for schizophrenia: Preliminary studies [J].
Keshavan, MS ;
Montrose, DM ;
Pierri, JN ;
Dick, EL ;
Rosenberg, D ;
Talagala, L ;
Sweeney, JA .
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 1997, 21 (08) :1285-1295
[17]   Decreased left amygdala and hippocampal volumes in young offspring at risk for schizophrenia [J].
Keshavan, MS ;
Dick, E ;
Mankowski, I ;
Harenski, K ;
Montrose, DM ;
Diwadkar, V ;
DeBellis, M .
SCHIZOPHRENIA RESEARCH, 2002, 58 (2-3) :173-183
[18]   A review of diffusion tensor imaging studies in schizophrenia [J].
Kubicki, Marek ;
McCarley, Robert ;
Westin, Carl-Fredrik ;
Park, Hae-Jeong ;
Maier, Stephan ;
Kikinis, Ron ;
Jolesz, Ferenc A. ;
Shenton, Martha E. .
JOURNAL OF PSYCHIATRIC RESEARCH, 2007, 41 (1-2) :15-30
[19]   Morphological classification of brains via high-dimensional shape transformations and machine learning methods [J].
Lao, ZQ ;
Shen, DG ;
Xue, Z ;
Karacali, B ;
Resnick, SM ;
Davatzikos, C .
NEUROIMAGE, 2004, 21 (01) :46-57
[20]   Brain abnormality in schizophrenia - A systematic and quantitative review of volumetric magnetic resonance imaging studies [J].
Lawrie, SM ;
Abukmeil, SS .
BRITISH JOURNAL OF PSYCHIATRY, 1998, 172 :110-120