Protonated chiral prolinamide catalyzed enantioselective direct aldol reaction in water

被引：101

作者：

Chimni, SS ^{[1
]}

Mahajan, D

Babu, VVS

机构：

[1] Guru Nanak Dev Univ, Dept Chem, Amritsar 143005, Punjab, India

[2] Bangalore Univ, Dept Studies Chem, Bangalore 560001, Karnataka, India

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 34期

关键词：

organocatalyst; aldol; enamine; water; prolinamide;

D O I：

10.1016/j.tetlet.2005.06.112

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Protonated chiral prolinamide organocatalysts have been shown to catalyze an enantioselective direct aldol process in water to provide the aldol product in high yield and good enantioselectivity. The two diastereomeric catalysts (S,R)-4b and (S,S)-4c show different reactivity. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：5617 / 5619

页数：3

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