High-lipid diet intake is a possible predisposing factor in the development of hypogonadal osteoporosis

被引：19

作者：

Chanda, S ^{[1
]}

Islam, MN ^{[1
]}

Pramanik, P ^{[1
]}

Mitra, C ^{[1
]}

机构：

[1] PRESIDENCY COLL,DEPT PHYSIOL,CALCUTTA,W BENGAL,INDIA

来源：

JAPANESE JOURNAL OF PHYSIOLOGY | 1996年 / 46卷 / 05期

关键词：

ovariectomy; high-lipid diet; intestinal transference and urinary loss of Ca2+; osteoporosis;

D O I：

10.2170/jjphysiol.46.383

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The effects of a high-lipid diet on the intestinal transference of Ca2+ and the activities of intestinal enzymes were studied in ovariectomized rats. The plasma Ca2+ level and urinary loss of Ca2+ were also observed. Ovariectomy decreased both alkaline phosphatase (AP) and calcium ATPase (Ca2+-ATPase) activity, and also reduced the mucosal transference of Ca2+ in all parts of the small intestine. Although the plasma Ca2+ level did not change significantly, the urinary loss of Ca2+ was enhanced. A high-lipid diet supplement enhanced all these parameters in ovariectomized rats. It is therefore believed that a high-lipid diet may promote osteoporosis in ovariectomized rats as the result of Ca2+ transfer and enhanced urinary Ca2+ loss.

引用

页码：383 / 388

页数：6

共 41 条

[21] EFFECT OF ENDOGENOUS ESTROGEN ON PLASMA AND URINARY CALCIUM AND PHOSPHATE IN OOPHORECTOMIZED WOMEN [J].