Protein export and drug efflux through bacterial channel-tunnels

被引：46

作者：

Andersen, C ^{[1
]}

Hughes, C ^{[1
]}

Koronakis, V ^{[1
]}

机构：

[1] Univ Cambridge, Dept Pathol, Cambridge CB2 1QP, England

来源：

CURRENT OPINION IN CELL BIOLOGY | 2001年 / 13卷 / 04期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/S0955-0674(00)00229-5

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The bacterial protein TolC assembles into an a-helical trans-periplasmic tunnel, which is embedded in the outer membrane by a contiguous beta -barrel channel. TolC and its homologues thus provide large exit ducts for a wide range of substrates, including protein toxins and antibacterial drugs, that are engaged by specific recognition proteins in the cytosolic membrane.

引用

页码：412 / 416

页数：5

共 38 条

[1] Chunnel vision - Export and efflux through bacterial channel-tunnels
Andersen, C
Hughes, C
Koronakis, V
[J]. EMBO REPORTS, 2000, 1 (04) : 313 - 318
[2] Involvement of outer membrane protein TolC, a possible member of the mar-sox regulon, in maintenance and improvement of organic solvent tolerance of Escherichia coli K-12
Aono, R
Tsukagoshi, N
Yamamoto, M
[J]. JOURNAL OF BACTERIOLOGY, 1998, 180 (04) : 938 - 944
[3] TOLC OF ESCHERICHIA-COLI FUNCTIONS AS AN OUTER-MEMBRANE CHANNEL
BENZ, R
MAIER, E
GENTSCHEV, I
[J]. ZENTRALBLATT FUR BAKTERIOLOGIE-INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY VIROLOGY PARASITOLOGY AND INFECTIOUS DISEASES, 1993, 278 (2-3): : 187 - 196
[4] Buchanan SK, 1999, NAT STRUCT BIOL, V6, P56
[5] MULTIPLE SEQUENCE ALIGNMENT WITH HIERARCHICAL-CLUSTERING
CORPET, F
[J]. NUCLEIC ACIDS RESEARCH, 1988, 16 (22) : 10881 - 10890
[6] CRYSTAL-STRUCTURES EXPLAIN FUNCTIONAL-PROPERTIES OF 2 ESCHERICHIA-COLI PORINS
COWAN, SW
SCHIRMER, T
RUMMEL, G
STEIERT, M
GHOSH, R
PAUPTIT, RA
JANSONIUS, JN
ROSENBUSCH, JP
[J]. NATURE, 1992, 358 (6389) : 727 - 733
[7] Crystal structure of MalK, the ATPase subunit of the trehalose/maltose ABC transporter of the archaeon Thermococcus litoralis
Diederichs, K
Diez, J
Greller, G
Müller, C
Breed, J
Schnell, C
Vonrhein, C
Boos, W
Welte, W
[J]. EMBO JOURNAL, 2000, 19 (22) : 5951 - 5961
[8] Tim23 links the inner and outer mitochondrial membranes
Donzeau, M
Káldi, K
Adam, A
Paschen, S
Wanner, G
Guiard, B
Bauer, MF
Neupert, W
Brunner, M
[J]. CELL, 2000, 101 (04) : 401 - 412
[9] Evidence that TolC is required for functioning of the Mar/AcrAB efflux pump of Escherichia coli
Fralick, JA
[J]. JOURNAL OF BACTERIOLOGY, 1996, 178 (19) : 5803 - 5805
[10] Delivery of protein antigens and DNA by virulence-attenuated strains of Salmonella typhimurium and Listeria monocytogenes
Gentschev, I
Dietrich, G
Spreng, S
Kolb-Mäurer, A
Daniels, J
Hess, J
Kaufmann, SHE
Goebel, W
[J]. JOURNAL OF BIOTECHNOLOGY, 2000, 83 (1-2) : 19 - 26

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