Detection and sequence analysis of hepatitis B virus integration in peripheral blood mononuclear cells

被引：35

作者：

Laskus, T

Radkowski, M

Wang, LF

Nowicki, M

Rakela, J

机构：

[1] Univ Pittsburgh, Med Ctr, Div Gastroenterol & Hepatol, Pittsburgh, PA 15213 USA

[2] Inst Infect Dis, Warsaw, Poland

[3] Univ So Calif, Maternal Child Virol Res Lab, Los Angeles, CA 90033 USA

来源：

JOURNAL OF VIROLOGY | 1999年 / 73卷 / 02期

关键词：

D O I：

10.1128/JVI.73.2.1235-1238.1999

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A PCR-based technique was used to detect hepatitis B virus (HBV) integration in peripheral blood mononuclear cells from patients with chronic hepatitis B. Integrated HBV DNA sequences, with virus-cell junctions located in the cohesive region between direct repeat 1 (DR1) and DR2, were found in 2 of 10 studied patients.

引用

收藏

页码：1235 / 1238

页数：4

相关论文

共 27 条

[11]

Kock J, 1996, HEPATOLOGY, V23, P405

[12] COMPILATION OF DNA STRAND EXCHANGE SITES FOR NON-HOMOLOGOUS RECOMBINATION IN SOMATIC-CELLS [J].

KONOPKA, AK .

NUCLEIC ACIDS RESEARCH, 1988, 16 (05) :1739-1758

[13]

KORBA BE, 1986, J VIROL, V58, P1

[14] Comparison of hepatitis B virus core promoter sequences in peripheral blood mononuclear cells and serum from patients with hepatitis B [J].

Laskus, T ;

Wang, LF ;

Radkowski, M ;

Vargas, H ;

Cianciara, J ;

Poutous, A ;

Rakela, J .

JOURNAL OF GENERAL VIROLOGY, 1997, 78 :649-653

[15] HEPATITIS-B VIRUS-DNA SEQUENCES IN LYMPHOID-CELLS FROM PATIENTS WITH AIDS AND AIDS-RELATED COMPLEX [J].

LAURE, F ;

ZAGURY, D ;

SAIMOT, AG ;

GALLO, RC ;

HAHN, BH ;

BRECHOT, C .

SCIENCE, 1985, 229 (4713) :561-563

[16] THE MODE OF HEPATITIS-B VIRUS-DNA INTEGRATION IN CHROMOSOMES OF HUMAN HEPATOCELLULAR-CARCINOMA [J].

NAGAYA, T ;

NAKAMURA, T ;

TOKINO, T ;

TSURIMOTO, T ;

IMAI, M ;

MAYUMI, T ;

KAMINO, K ;

YAMAMURA, K ;

MATSUBARA, K .

GENES & DEVELOPMENT, 1987, 1 (08) :773-782

[17] DETECTION OF HEPATITIS-B VIRUS-DNA IN MONONUCLEAR BLOOD-CELLS [J].

PONTISSO, P ;

POON, MC ;

TIOLLAIS, P ;

BRECHOT, C .

BRITISH MEDICAL JOURNAL, 1984, 288 (6430) :1563-1566

[18] MAPPING INVIVO TOPOISOMERASE-I SITES ON SIMIAN VIRUS-40 DNA - ASYMMETRIC DISTRIBUTION OF SITES ON REPLICATING MOLECULES [J].

PORTER, SE ;

CHAMPOUX, JJ .

MOLECULAR AND CELLULAR BIOLOGY, 1989, 9 (02) :541-550

[19] The hepatitis B virus persists for decades after patients' recovery from acute viral hepatitis despite active maintenance of a cytotoxic T-lymphocyte response [J].

Rehermann, B ;

Ferrari, C ;

Pasquinelli, C ;

Chisari, FV .

NATURE MEDICINE, 1996, 2 (10) :1104-1108

[20]

SORENSEN AB, 1993, J VIROL, V67, P7118