Epidermal Notch signalling: differentiation, cancer and adhesion

被引：302

作者：

Watt, Fiona M. ^{[1
,2
]}

Estrach, Soline ^{[2
]}

Ambler, Carrie A. ^{[1
]}

机构：

[1] Li Ka Shing Ctr, Canc Res UK Cambridge Res Inst, Cambridge CB2 0RE, England

[2] Wellcome Trust Ctr Stem Cell Res, Cambridge CB2 1QR, England

来源：

CURRENT OPINION IN CELL BIOLOGY | 2008年 / 20卷 / 02期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

D O I：

10.1016/j.ceb.2008.01.010

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

The Notch pathway plays an important role in regulating epidermal differentiation. Notch ligands, receptors and effectors are expressed in a complex and dynamic pattern in embryonic and adult skin. Genetic ablation or activation of the pathway reveals that Notch signalling promotes differentiation of the hair follicle, sebaceous gland and interfollicular epidermal lineages and that Notch acts as an epidermal tumour suppressor. Notch signalling interacts with a range of other pathways to fulfil these functions and acts via RBP-J kappa dependent and independent mechanisms. The effects on differentiation can be cell autonomous and non-autonomous, and Notch contributes to stem cell clustering via modulation of cell adhesion.

引用

页码：171 / 179

页数：9

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