Clinical and virologic outcomes in patients with oseltamivir-resistant seasonal influenza A (H1N1) infections: results from a clinical trial

被引：5

作者：

Dharan, Nila J. ^{[1
]}

Fry, Alicia M.

Kieke, Burney A. ^{[2
]}

Coleman, Laura ^{[2
]}

Meece, Jennifer ^{[2
]}

Vandermause, Mary ^{[2
]}

Gubareva, Larisa V.

Klimov, Alexander I.

Belongia, Edward A. ^{[2
]}

机构：

[1] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Off Workforce & Career Dev, Influenza Div, Atlanta, GA USA

[2] Marshfield Clin Res Fdn, Marshfield, WI USA

来源：

INFLUENZA AND OTHER RESPIRATORY VIRUSES | 2012年 / 6卷 / 03期

关键词：

Antiviral; influenza; oseltamivir effectiveness; resistance; NEURAMINIDASE INHIBITORS; VIRUS; SUSCEPTIBILITY; ZANAMIVIR; H5N1;

D O I：

10.1111/j.1750-2659.2011.00312.x

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Nineteen patients with oseltamivir-resistant seasonal influenza A (H1N1) infections were randomized to receive oseltamivir or placebo. Nasopharyngeal swabs were obtained, and clinical and virologic outcomes were compared, stratified by early or late treatment. Neuraminidase inhibition assay and pyrosequencing for H275Y confirmed resistance. Twelve (63%) patients received oseltamivir; 8 (67%) received late treatment. Seven (37%) patients received placebo; 6 (86%) presented >48 hours after onset. Time to 50% decrease in symptom severity, complete symptom resolution, and first negative culture were shortest among the early treatment group. While sample size prohibits a strong conclusion, future studies should evaluate for similar trends.

引用

页码：153 / 158

页数：6

共 17 条

[1] Effectiveness of Inactivated Influenza Vaccines Varied Substantially with Antigenic Match from the 2004-2005 Season to the 2006-2007 Season [J].

Belongia, Edward A. ;

Kieke, Burney A. ;

Donahue, James G. ;

Greenlee, Robert T. ;

Balish, Amanda ;

Foust, Angie ;

Lindstrom, Stephen ;

Shay, David K. .

JOURNAL OF INFECTIOUS DISEASES, 2009, 199 (02) :159-167

[2] Pyrosequencing as a tool to detect molecular markers of resistance to neuraminidase inhibitors in seasonal influenza A viruses [J].

Deyde, Varough M. ;

Okomo-Adhiambo, Margaret ;

Sheu, Tiffany G. ;

Wallis, Teresa R. ;

Fry, Alicia ;

Dharan, Nila ;

Klimov, Alexander I. ;

Gubareva, Larisa V. .

ANTIVIRAL RESEARCH, 2009, 81 (01) :16-24

[3] Flexible smoothing with B-splines and penalties [J].

Eilers, PHC ;

Marx, BD .

STATISTICAL SCIENCE, 1996, 11 (02) :89-102

[4] Detection of influenza virus resistance to neuraminidase inhibitors by an enzyme inhibition assay [J].

Gubareva, LV ;

Webster, RG ;

Hayden, FG .

ANTIVIRAL RESEARCH, 2002, 53 (01) :47-61

[5] Evidence for zanamivir resistance in an immunocompromised child infected with influenza B virus [J].

Gubareva, LV ;

Matrosovich, MN ;

Brenner, MK ;

Bethell, RC ;

Webster, RG .

JOURNAL OF INFECTIOUS DISEASES, 1998, 178 (05) :1257-1262

[6] Clinical Effectiveness of Oseltamivir and Zanamivir for Treatment of Influenza A Virus Subtype H1N1 with the H274Y Mutation: A Japanese, Multicenter Study of the 2007-2008 and 2008-2009 Influenza Seasons [J].

Kawai, Naoki ;

Ikematsu, Hideyuki ;

Hirotsu, Nobuo ;

Maeda, Tetsunari ;

Kawashima, Takashi ;

Tanaka, Osame ;

Yamauchi, Satoshi ;

Kawamura, Kenichi ;

Matsuura, Shinro ;

Nishimura, Mika ;

Iwaki, Norio ;

Kashiwagi, Seizaburo .

CLINICAL INFECTIOUS DISEASES, 2009, 49 (12) :1828-1835

[7] Clinical effectiveness of oseltamivir for influenza A(H1N1) virus with H274Y neuraminidase mutation [J].

Kawai, Naoki ;

Ikematsu, Hideyuki ;

Iwaki, Norio ;

Kondou, Kunio ;

Hirotsu, Nobuo ;

Kawashima, Takashi ;

Maeda, Tetsunari ;

Tanaka, Osame ;

Doniwa, Ken-ichi ;

Kashiwagi, Seizaburo .

JOURNAL OF INFECTION, 2009, 59 (03) :207-212

[8] Characterization of Oseltamivir-Resistant 2009 H1N1 Pandemic Influenza A Viruses [J].

Kiso, Maki ;

Shinya, Kyoko ;

Shimojima, Masayuki ;

Takano, Ryo ;

Takahashi, Kei ;

Katsura, Hiroaki ;

Kakugawa, Satoshi ;

Mai Thi Quynh Le ;

Yamashita, Makoto ;

Furuta, Yousuke ;

Ozawa, Makoto ;

Kawaoka, Yoshihiro .

PLOS PATHOGENS, 2010, 6 (08) :97-98

[9] Oseltamivir distributes to influenza virus replication sites in the middle ear and sinuses [J].

Kurowski, M ;

Oo, C ;

Wiltshire, H ;

Barrett, J .

CLINICAL DRUG INVESTIGATION, 2004, 24 (01) :49-53

[10] Avian flu - Isolation of drug-resistant H5N1 virus [J].

Le, QM ;

Kiso, M ;

Someya, K ;

Sakai, YT ;

Nguyen, TH ;

Nguyen, KHL ;

Pham, ND ;

Ngyen, HH ;

Yamada, S ;

Muramoto, Y ;

Horimoto, T ;

Takada, A ;

Goto, H ;

Suzuki, T ;

Suzuki, Y ;

Kawaoka, Y .

NATURE, 2005, 437 (7062) :1108-1108

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