Physical analysis of a processive molecular motor: The conventional kinesin

被引:3
作者
Ciudad, A
Lacasta, AM
Sancho, JM
机构
[1] Univ Barcelona, Fac Fis, Dept Estructura & Constituents Mat, E-08028 Barcelona, Spain
[2] Univ Politecn Cataluna, Dept Fis Aplicada, E-08028 Barcelona, Spain
来源
PHYSICAL REVIEW E | 2005年 / 72卷 / 03期
关键词
D O I
10.1103/PhysRevE.72.031918
中图分类号
O35 [流体力学]; O53 [等离子体物理学];
学科分类号
070204 ; 080103 ; 080704 ;
摘要
We present a model that allows for the derivation of the experimentally accesible observables: spatial steps, mean velocity, stall force, useful power, efficiency and randomness, etc. as a function of the [adenosine triphosphate] concentration and an external load F. The model presents a minimum of adjustable parameters and the theoretical predictions compare well with the available experimental results.
引用
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页数:6
相关论文
共 21 条
[1]  
[Anonymous], 2001, MECH MOTOR PROTEINS
[2]  
ASBURY CL, 2003, SCIENCE, V2130, P302
[3]  
Astumian D, 2003, AIP CONF PROC, V658, P221, DOI 10.1063/1.1566657
[4]   Processive motor protein as an overdamped brownian stepper [J].
Bier, M .
PHYSICAL REVIEW LETTERS, 2003, 91 (14)
[5]   Probing the kinesin reaction cycle with a 2D optical force clamp [J].
Block, SM ;
Asbury, CL ;
Shaevitz, JW ;
Lang, MJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (05) :2351-2356
[6]   The physics of molecular motors [J].
Bustamante, C ;
Keller, D ;
Oster, G .
ACCOUNTS OF CHEMICAL RESEARCH, 2001, 34 (06) :412-420
[7]   The loud dependence of kinesin's mechanical cycle [J].
Coppin, CM ;
Pierce, DW ;
Hsu, L ;
Vale, RD .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (16) :8539-8544
[8]   Simple mechanochemistry describes the dynamics of kinesin molecules [J].
Fisher, ME ;
Kolomeisky, AB .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (14) :7748-7753
[9]   Novel method for measurement of submembrane ATP concentration [J].
Gribble, FM ;
Loussouarn, G ;
Tucker, SJ ;
Zhao, C ;
Nichols, CG ;
Ashcroft, FM .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (39) :30046-30049
[10]   ATP consumption and efficiency of human single muscle fibers with different myosin isoform composition [J].
He, ZH ;
Bottinelli, R ;
Pellegrino, MA ;
Ferenczi, MA ;
Reggiani, C .
BIOPHYSICAL JOURNAL, 2000, 79 (02) :945-961