Total synthesis of FR901483

被引：69

作者：

Ousmer, M

Braun, NA

Ciufolini, MA

机构：

[1] Univ Lyon 1, LSMO, F-69622 Villeurbanne, France

[2] Ecole Super Chim Phys Elect Lyon, F-69622 Villeurbanne, France

[3] Rice Univ, Dept Chem, Houston, TX 77005 USA

来源：

ORGANIC LETTERS | 2001年 / 3卷 / 05期

关键词：

D O I：

10.1021/ol015526i

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] The total synthesis of FR901483, a structurally novel immunosuppressant, has been accomplished by the use of technology recently developed in this laboratory for the oxidative cyclization of phenolic oxazolines to spirolactams. Our approach may reflect the biosynthetic pathway leading to the natural product.

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页码：765 / 767

页数：3

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