Rfam: Wikipedia, clans and the "decimal" release

被引:290
作者
Gardner, Paul P. [1 ]
Daub, Jennifer [1 ]
Tate, John [1 ]
Moore, Benjamin L. [1 ]
Osuch, Isabelle H. [1 ]
Griffiths-Jones, Sam [2 ]
Finn, Robert D. [3 ]
Nawrocki, Eric P. [3 ]
Kolbe, Diana L. [3 ]
Eddy, Sean R. [3 ]
Bateman, Alex [1 ]
机构
[1] Wellcome Trust Sanger Inst, Hinxton CB10 1SA0, England
[2] Univ Manchester, Fac Life Sci, Manchester M13 9PL, Lancs, England
[3] Howard Hughes Med Inst, Ashburn, VA 20147 USA
基金
英国惠康基金;
关键词
RNA SECONDARY STRUCTURE; SMALL NUCLEOLAR RNAS; COMPREHENSIVE DATABASE; NONCODING RNA; FAMILY; SEQUENCE; ANNOTATION; ONTOLOGY; SNORNA; H/ACA;
D O I
10.1093/nar/gkq1129
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The Rfam database aims to catalogue non-coding RNAs through the use of sequence alignments and statistical profile models known as covariance models. In this contribution, we discuss the pros and cons of using the online encyclopedia, Wikipedia, as a source of community-derived annotation. We discuss the addition of groupings of related RNA families into clans and new developments to the website. Rfam is available on the Web at http://rfam.sanger.ac.uk.
引用
收藏
页码:D141 / D145
页数:5
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