Expression of the p75 neurotrophin receptor in acute leukaemia

被引：17

作者：

Beutel, G

Meyer, J

Ma, LP

Yin, SM

Eder, M

von Neuhoff, N

Wilkens, L

Wei, J

Hertenstein, B

Heil, G

Schlegelberger, B

Ganser, A

Li, ZX

Baum, C

机构：

[1] Hannover Med Sch, Dept Haematol Haemostasis & Oncol, D-30625 Hannover, Germany

[2] Sun Yat Sen Mem Hosp, Haematol & Med Res Ctr, Guangzhou, Peoples R China

[3] Hannover Med Sch, Inst Cellular & Mol Pathol, D-30625 Hannover, Germany

[4] Cincinnati Childrens Res Fdn, Div Expt Haematol, Cincinnati, OH USA

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2005年 / 131卷 / 01期

关键词：

p75NTR; acute leukaemia;

D O I：

10.1111/j.1365-2141.2005.05717.x

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

The dLNGFR is a cytoplasmically deleted form of the low-affinity nerve growth factor receptor (LNGFR, also known as p75NTR). Recently, we observed a myeloid leukaemia in mice transplanted with dLNGFR-modified bone marrow cells. Retroviral-mediated expression of dLNGFR was suspected to contribute to the murine leukaemia. This led us to investigate the expression of p75NTR in human leukaemia. Expression of p75NTR was observed in nine of 119 (8%) adult patients with acute leukaemia by flow cytometry analysis, particularly in acute lymphoblastic leukaemia (26%). These results support further detailed analyses of neurotrophin receptors and downstream signalling pathways in haematological malignancies.

引用

页码：67 / 70

页数：4

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