The domino blocks: A simple solution for parallel solid-phase organic synthesis

被引：32

作者：

Krchnak, V

Padera, V

机构：

[1] SIDDCO, Tucson, AZ 85747 USA

[2] Torviq, Tucson, AZ 85742 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 22期

关键词：

D O I：

10.1016/S0960-894X(98)00594-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The domino block is a reaction block for manual and semi-automatic parallel solid-phase organic synthesis that simplifies liquid exchange and integrates common synthetic steps. The domino block consists of enclosed reaction vessels, polypropylene syringes, attached to a manifold that clamps the syringes and connects them to a common port. Liquid is removed from the closed reaction vessels by vacuum connected to the common port. The vacuum formed inside each reaction vessel is subsequently used to draw fresh solvent or reagent into each reaction vessel. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：3261 / 3264

页数：4

共 9 条

[1] New methods in combinatorial chemistry - robotics and parallel synthesis
Cargill, JF
Lebl, M
[J]. CURRENT OPINION IN CHEMICAL BIOLOGY, 1997, 1 (01) : 67 - 71
[2] GENERAL-METHOD FOR THE RAPID SOLID-PHASE SYNTHESIS OF LARGE NUMBERS OF PEPTIDES - SPECIFICITY OF ANTIGEN-ANTIBODY INTERACTION AT THE LEVEL OF INDIVIDUAL AMINO-ACIDS
HOUGHTEN, RA
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (15) : 5131 - 5135
[3] KRCHNAK V, 1990, Peptide Research, V3, P182
[4] Automated solid-phase organic synthesis in micro-plate wells. Synthesis of N-(alkoxy-acyl)amino alcohols
Krchnak, V
Weichsel, AS
Lebl, M
Felder, S
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1997, 7 (08) : 1013 - 1016
[5] Structurally homogeneous and heterogeneous synthetic combinatorial libraries
Krchnak, V
Weichsel, AS
Cabel, D
Flegelova, Z
Lebl, M
[J]. MOLECULAR DIVERSITY, 1996, 1 (03) : 149 - 164
[6] The ''one-bead-one-compound'' combinatorial library method
Lam, KS
Lebl, M
Krchnak, V
[J]. CHEMICAL REVIEWS, 1997, 97 (02) : 411 - 448
[7] LEBL M, 1998, SOLID PHASE SYNTHESI
[8] RADIO-FREQUENCY TAG ENCODED COMBINATORIAL LIBRARY METHOD FOR THE DISCOVERY OF TRIPEPTIDE-SUBSTITUTED CINNAMIC ACID INHIBITORS OF THE PROTEIN-TYROSINE-PHOSPHATASE PTP1B
MORAN, EJ
SARSHAR, S
CARGILL, JF
SHAHBAZ, MM
LIO, A
MJALLI, AMM
ARMSTRONG, RW
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1995, 117 (43) : 10787 - 10788
[9] RADIOFREQUENCY ENCODED COMBINATORIAL CHEMISTRY
NICOLAOU, KC
XIAO, XY
PARANDOOSH, Z
SENYEI, A
NOVA, MP
[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1995, 34 (20): : 2289 - 2291

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