Excellent Correlation between Drug Release and Portal Size in Metalla-Cage Drug-Delivery Systems

被引：85

作者：

Barry, Nicolas P. E. ^{[2
]}

Zava, Olivier ^{[1
]}

Dyson, Paul J. ^{[1
]}

Therrien, Bruno ^{[2
]}

机构：

[1] Ecole Polytech Fed Lausanne, Inst Sci & Ingn Chim, CH-1015 Lausanne, Switzerland

[2] Univ Neuchatel, Inst Chem, CH-2000 Neuchatel, Switzerland

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2011年 / 17卷 / 35期

关键词：

bioorganometallic chemistry; drug delivery; endocytosis; host-guest systems; ruthenium; ARENE RUTHENIUM COMPLEXES; ANTICANCER DRUGS; GUEST EXCHANGE; PHASE-I; ENCAPSULATION; COORDINATION; THERAPEUTICS; CONJUGATE; CHEMISTRY; BINDING;

D O I：

10.1002/chem.201003530

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of large cationic hexanuclear metalla-prisms, [Ru-6(p-iPrC(6)H(4)Me)(6)(tpt)(2)(donq)(3)](6+), [Ru-6(p-iPrC(6)H(4)Me)(6)(tpt)(2)(doaq)(3)](6+) and [Ru-6(p-iPrC(6)H(4)Me)(6)(tpt)(2)(dotq)(3)](6+), composed of p-cymene-ruthenium building blocks bridged by OO boolean AND OO ligands (donq = 5,8-dioxido-1,4-naphthoquinonato; doaq = 5,8-dioxido-1,4-anthraquinonato, dotq = 6,11-dioxido-5,12-naphthacenedionato) and connected by two 2,4,6-tripyridin-4-yl-1,3,5-triazine (tpt) panels, which encapsulate the guest molecules 1-(4,6-dichloro-1,3,5-triazin-2-yl)pyrene and Pd(acac)(2), have been prepared. The host-guest properties of these water-soluble delivery systems were studied in solution by NMR and fluorescence spectroscopy, providing the stability constants (K) for these host-guest systems. Moreover, the ability of the hosts to deliver the guests into cancer cells was evaluated and the uptake mechanism studied; the rate of release of the guest molecule was found to depend on the portal size of the host.

引用

页码：9669 / 9677

页数：9

共 80 条

[11] Highly efficient quenching of excimer fluorescence by perylene diimide in DNA [J].

Bouquin, Nicolas ;

Malinovskii, Vladimir L. ;

Haener, Robert .

CHEMICAL COMMUNICATIONS, 2008, (17) :1974-1976

[12]

*BRUK BIOSPIN, 2005, TOPSPIN SOFTW VERS 2

[13]

*C ZEISS MICROIMAG, 2007, ZEN SOFTW

[14] Phase I and pharmacokinetic trial of AP5346, a DACH-platinum-polymer conjugate, administered weekly for three out of every 4 weeks to advanced solid tumor patients [J].

Campone, Mario ;

Rademaker-Lakhai, Jeany M. ;

Bennouna, Jaafar ;

Howell, Stephen B. ;

Nowotnik, David P. ;

Beijnen, Jos H. ;

Schellens, Jan H. M. .

CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2007, 60 (04) :523-533

[15] Mechanised nanoparticles for drug delivery [J].

Coti, Karla K. ;

Belowich, Matthew E. ;

Liong, Monty ;

Ambrogio, Michael W. ;

Lau, Yuen A. ;

Khatib, Hussam A. ;

Zink, Jeffrey I. ;

Khashab, Niveen M. ;

Stoddart, J. Fraser .

NANOSCALE, 2009, 1 (01) :16-39

[16] Dimolybdenum-containing molecular triangles and squares with diamidate linkers: Structural diversity and complexity [J].

Cotton, FA ;

Liu, CY ;

Murillo, CA ;

Wang, XP .

INORGANIC CHEMISTRY, 2006, 45 (06) :2619-2626

[17] Metallo-supramolecular capsules [J].

Dalgarno, Scott J. ;

Power, Nicholas P. ;

Atwood, Jerry L. .

COORDINATION CHEMISTRY REVIEWS, 2008, 252 (8-9) :825-841

[18] The big squeeze:: Guest exchange in an M4L6 supramolecular host [J].

Davis, AV ;

Raymond, KN .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (21) :7912-7919

[19] A unique type of a dicobalt cage templated by a weakly coordinated hexafluorophosphate anion: design, structure and solid-state NMR investigations [J].

Desmarets, Christophe ;

Poli, Fabrizia ;

Le Goff, Xavier F. ;

Mueller, Klaus ;

Amouri, Hani .

DALTON TRANSACTIONS, 2009, (47) :10429-10432

[20] Metal-based antitumour drugs in the post genomic era [J].

Dyson, PJ ;

Sava, G .

DALTON TRANSACTIONS, 2006, (16) :1929-1933

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