Antinociceptive activity of the volatile oils of Hyptis pectinata L. Poit. (Lamiaceae) genotypes

被引：32

作者：

Arrigoni-Blank, M. F. ^{[1
]}

Antoniolli, A. R. ^{[2
]}

Caetano, L. C. ^{[3
]}

Campos, D. A. ^{[4
]}

Blank, A. F. ^{[4
]}

Alves, P. B. ^{[5
]}

机构：

[1] Univ Fed Sergipe, Nucleo Ciencias Biol, BR-49500000 Sergipe, Brazil

[2] Univ Fed Sergipe, Dept Fisiol, Sao Cristovao, Sergipe, Brazil

[3] Univ Fed Alagoas, Dept Quim, Maceio, Alagoas, Brazil

[4] Univ Fed Sergipe, Dept Engn Agron, Sao Cristovao, Sergipe, Brazil

[5] Univ Fed Sergipe, Dept Quim, Sao Cristovao, Sergipe, Brazil

来源：

PHYTOMEDICINE | 2008年 / 15卷 / 05期

关键词：

Hyptis pectinata; acetic-acid-induced abdominal constrictions; hot-plate test; acute toxicity; native medicinal plant;

D O I：

10.1016/j.phymed.2007.09.009

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Hyptis pectinata L. Poit (Lamiaceae) is known popularly in Brazil as "sambacaita" or "canudinho" and is used in the treatment of inflammations, bacterial infections and ache. The antinociceptive activity of the volatile oils of six genotypes, at doses of 100, 200 and 400 mg/kg body wt., were investigated using abdominal writhe models induced by acetic acid and hot plate tests. the volatile oils of all the genotypes are composed mainly of sesquiterpenoids. All the genotypes showed antinociceptive effects in both models used; the SAM002 genotype showed the major inhibitory effect at dose of 100 mg/kg body wt. These results suggest that the volatile oil of H. pectinata has peripheral (writhe reduction) and central (time delay of thermal reaction) effects. These observations indicate that H. pectinata may be useful as an analgesic drug. (c) 2007 Elsevier GmbH. All rights reserved.

引用

页码：334 / 339

页数：6

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