An optimised in situ procedure for the oxazaborolidine catalysed enantioselective reduction of prochiral ketones

被引：37

作者：

Prasad, KRK ^{[1
]}

Joshi, NN ^{[1
]}

机构：

[1] NATL CHEM LAB,DIV ORGAN SYNTH,PUNE 411008,MAHARASHTRA,INDIA

来源：

TETRAHEDRON-ASYMMETRY | 1996年 / 7卷 / 11期

关键词：

D O I：

10.1016/0957-4166(96)00416-8

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A systematic study was conducted to formulate the optimal reaction parameters for the oxazaborolidine catalysed enantioselective reduction. The catalyst derived from diphenyl prolinol was found to be the best amongst several other analogues and a reduction temperature of 45 degrees C is recommended for high enantioselectivity (92-99% ee) for the reduction of alkyl aryl ketones. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：3147 / 3152

页数：6

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