Absence of IgG1 response in the cerebrospinal fluid of relapsing neuromyelitis optica

被引：24

作者：

Nakashima, I ^{[1
]}

Fujihara, K ^{[1
]}

Fujimori, J ^{[1
]}

Narikawa, K ^{[1
]}

Misu, T ^{[1
]}

Itoyama, Y ^{[1
]}

机构：

[1] Tohoku Univ, Sch Med, Dept Neurol, Aoba Ku, Sendai, Miyagi 9808574, Japan

来源：

NEUROLOGY | 2004年 / 62卷 / 01期

关键词：

D O I：

10.1212/WNL.62.1.144

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The authors studied immunoglobulin (Ig) G subclasses in the CSF and sera of patients with relapsing neuromyelitis optica (RNMO) and typical multiple sclerosis ( MS). Although the total IgG concentrations were elevated in the CSF of patients with RNMO and MS, IgG1% and IgG1 index were significantly elevated only in patients with MS. The absence of the CSF IgG1 responses in the patients with RNMO may suggest less Th1 immunity and may also explain the rarity of oligoclonal IgG bands in patients with this disease.

引用

页码：144 / 146

页数：3

共 10 条

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