Regulation of heptaspanning-membrane-receptor function by dimerization and clustering

被引:71
作者
Franco, R
Canals, M
Marcellino, D
Ferré, S
Agnati, L
Mallol, J
Casadó, V
Ciruela, F
Fuxe, K
Lluis, C
Canela, EI
机构
[1] Univ Barcelona, Dept Biochem Mol Biol, E-08028 Barcelona, Spain
[2] NIDA, Preclin Pharmacol Sect, US Dept HHS, NIH,IRP, Baltimore, MD 21224 USA
[3] Univ Modena, Dept Biomed Sci, Physiol Sect, I-41100 Modena, Italy
[4] Dept Rehabil, Ludes, Paradiso, Switzerland
[5] Karolinska Inst, Div Cell & Mol Neurochem, Dept Neurosci, S-17177 Stockholm, Sweden
关键词
D O I
10.1016/S0968-0004(03)00065-3
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
G-protein-coupled receptors form homomers and heteromers; agonist-induced conformational changes within interacting receptors of the oligomer modify their pharmacology, signalling and/or trafficking. When these receptors are activated, the oligomers rearrange and cluster and a novel mechanism of receptor-operation regulation by oligomer intercommunication is possible. This intercommunication would be assisted by components of the plasma membrane and by scaffolding proteins. Receptor cross-sensitization, cross-desensitization and novel, integrated receptor responses can then develop between oligomeric receptor complexes of the cluster without direct contact between them. This concept gives a new perspective to the understanding of neurotransmission and neuronal plasticity.
引用
收藏
页码:238 / 243
页数:6
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