Early localization of mRNA coding for 5-HT1A receptors in human brain during development

被引：40

作者：

del Olmo, E

López-Giménez, JF

Vilaró, MT

Mengod, G

Palacios, JM

Pazos, A

机构：

[1] Univ Cantabria, Fac Med, Pharmacol Unit, Dept Physiol & Pharmacol, Santander 39011, Spain

[2] Inst Invest Biomed Barcelona, Dept Neurochem, Barcelona 08034, Spain

[3] Almirall Prodesfarma Labs, Res Ctr, Barcelona, Spain

来源：

MOLECULAR BRAIN RESEARCH | 1998年 / 60卷 / 01期

关键词：

mRNA 5-HT1A receptor; human brain; development; in situ hybridization; prenatal; cerebellum; hippocampus; raphe nucleus;

D O I：

10.1016/S0169-328X(98)00149-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The distribution of 5-HT1A receptor mRNA in the human brain was studied in neonatal, children and adult cases by means of in situ hybridization histochemistry, using an oligonucleotide derived from the coding region of the human receptor. A prenatal pattern of development was observed, The hippocampus, raphe nuclei and neocortex presented high levels of hybridization already at the fetal/neonatal stage, fully comparable to the adult. A high and transient hybridization signal was found in cerebellum. These results support a role for 5-HT1A receptors in the regulation of neural development. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：123 / 126

页数：4

共 17 条

[1] FETAL HUMAN BRAIN EXHIBITS A PRENATAL PEAK IN THE DENSITY OF SEROTONIN 5-HT1A RECEPTORS [J].