Synthetic bolaamphiphilic analogs of galactosylceramide (GalCer) potentially binding to the V3 domain of HIV-1 gp 120: key role of their hydrophobicity

被引：18

作者：

Rico-Lattes, I ^{[1
]}

Gouzy, MF ^{[1
]}

Andre-Barres, C ^{[1
]}

Guidetti, B ^{[1
]}

Lattes, A ^{[1
]}

机构：

[1] Univ Toulouse 3, CNRS, URA 5623, Lab IMRCP, F-31062 Toulouse, France

来源：

NEW JOURNAL OF CHEMISTRY | 1998年 / 22卷 / 05期

关键词：

D O I：

10.1039/a709184b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

New routes in three or four steps to synthetic bolaamphiphilic analogs of galactosylceramide (GalCer) are presented in this work, using unprotected lactose as the starting sugar. Some of these new anionic compounds obtained in good yields bind to the V3 domain of HIV-1 gp 120 and thus are the base of potential low-cost anti HIV-1 drugs. Moreover, structure-activity relationships show that the hydrophobic moiety of the molecule plays a key role in this activity.

引用

页码：451 / 457

页数：7

共 20 条

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