Use of QSARs in international decision-making frameworks to predict ecologic effects and environmental fate of chemical substances

被引：154

作者：

Cronin, MTD

Walker, JD

Jaworska, JS

Comber, MHI

Watts, CD

Worth, AP

机构：

[1] Liverpool John Moores Univ, Sch Pharm & Chem, Liverpool L3 3AF, Merseyside, England

[2] US EPA, Tox Subst Control Act Interagcy, Testing Comm, Washington, DC 20460 USA

[3] Procter & Gamble Co, Strombeek Bever, Belgium

[4] ExxonMobil Biomed Sci Inc, Prod Stewardship & Regulatory Affairs, Machelen, Belgium

[5] NSF, WRc, Natl Ctr Environm Toxicol, Marlow, Bucks, England

[6] European Commiss, European Chem Bur, Inst Hlth & Consumer Protect, Joint Res Ctr, Ispra, Italy

来源：

ENVIRONMENTAL HEALTH PERSPECTIVES | 2003年 / 111卷 / 10期

关键词：

bioaccumulation; chemical substances; persistence; QSAR; regulatory agencies; toxicity;

D O I：

10.1289/ehp.5759

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

This article is a review of the use, by regulatory agencies and authorities, of quantitative structure-activity relationships (QARs) to predict ecologic effects and environmental fate of chemicals. For many years, the U.S. Environmental Protection Agency has been the most prominent regulatory agency using QSARs to predict the ecologic effects and environmental fate of chemicals. However, as increasing numbers of standard QSAR methods are developed and validated to predict ecologic effects and environmental fate of chemicals, it is anticipated that more regulatory agencies and authorities will find them to be acceptable alternatives to chemical testing.

引用

页码：1376 / 1390

页数：15

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