iMAT: an integrative metabolic analysis tool

被引：227

作者：

Zur, Hadas ^{[1
]}

Ruppin, Eytan ^{[1
,2
]}

Shlomi, Tomer ^{[3
]}

机构：

[1] Tel Aviv Univ, Blavatnik Sch Comp Sci, IL-69978 Tel Aviv, Israel

[2] Tel Aviv Univ, Sackler Fac Exact Sci, Sackler Sch Med, IL-69978 Tel Aviv, Israel

[3] Technion Israel Inst Technol, Dept Comp Sci, IL-32000 Haifa, Israel

来源：

BIOINFORMATICS | 2010年 / 26卷 / 24期

基金：

以色列科学基金会;

关键词：

GENE-EXPRESSION DATA; SACCHAROMYCES-CEREVISIAE; NETWORK; MODELS;

D O I：

10.1093/bioinformatics/btq602

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

iMAT is an Integrative Metabolic Analysis Tool, enabling the integration of transcriptomic and proteomic data with genome scale metabolic network models to predict enzymes' metabolic flux, based on the method previously described by Shlomi et al. The prediction of metabolic fluxes based on high-throughput molecular data sources could help to advance our understanding of cellular metabolism, since current experimental approaches are limited to measuring fluxes through merely a few dozen enzymes.

引用

页码：3140 / 3142

页数：3

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