Applications of genome-scale metabolic reconstructions

被引：578

作者：

Oberhardt, Matthew A. ^{[1
]}

Palsson, Bernhard O. ^{[2
]}

Papin, Jason A. ^{[1
]}

机构：

[1] Univ Virginia, Dept Biomed Engn, Charlottesville, VA 22908 USA

[2] Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA

来源：

MOLECULAR SYSTEMS BIOLOGY | 2009年 / 5卷

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

computational biology; metabolic model; modeling; network; systems biology; FLUX BALANCE ANALYSIS; HAEMOPHILUS-INFLUENZAE RD; CONSTRAINT-BASED ANALYSIS; NETWORK-BASED PREDICTION; SACCHAROMYCES-CEREVISIAE; STAPHYLOCOCCUS-AUREUS; MYCOBACTERIUM-TUBERCULOSIS; SYSTEMS-ANALYSIS; TRANSCRIPTIONAL REGULATION; GEOBACTER-SULFURREDUCENS;

D O I：

10.1038/msb.2009.77

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The availability and utility of genome-scale metabolic reconstructions have exploded since the first genome-scale reconstruction was published a decade ago. Reconstructions have now been built for a wide variety of organisms, and have been used toward five major ends: (1) contextualization of high-throughput data, (2) guidance of metabolic engineering, (3) directing hypothesis-driven discovery, (4) interrogation of multi-species relationships, and (5) network property discovery. In this review, we examine the many uses and future directions of genome-scale metabolic reconstructions, and we highlight trends and opportunities in the field that will make the greatest impact on many fields of biology. Molecular Systems Biology 5: 320; published online 3 November 2009; doi: 10.1038/msb.2009.77

引用

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