Gonadotropin-regulated testicular helicase (GRTH/DDX25): an essential regulator of spermatogenesis

被引：48

作者：

Dufau, Maria L. ^{[1
]}

Tsai-Morris, Chon-Hwa

机构：

[1] NICHHD, Sect Mol Endocrinol, NIH, Bethesda, MD 20892 USA

[2] NICHHD, Res Reprod Branch, NIH, Bethesda, MD 20892 USA

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2007年 / 18卷 / 08期

关键词：

D O I：

10.1016/j.tem.2007.09.001

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Male germ-cell maturation is orchestrated by a cascade of temporally regulated factors. Gonadotropin-regulated testicular helicase (GRTH/DDX25), a target of gonadotropin and androgen action, is a post-transcriptional regulator of key spermatogenesis genes. Male mice lacking GRTH are sterile, with spermatogenic arrest owing to the failure of round spermatids to elongate. GIRTH is a component of messenger ribonucleoprotein particles, which transport target mRNAs to the cytoplasm for storage in chromatoid bodies of spermatids; these messages are released for translation during spermatogenesis. GIRTH is also found in polyribosomes, where it regulates the translation of mRNAs encoding spermatogenesis factors. The association of GRTH mutations with male infertility underlines the importance of GRTH as a central, post-transcriptional regulator of spermatogenesis.

引用

页码：314 / 320

页数：7

共 63 条

[1] RNA, helicases: Regulators of differentiation [J].

Abdelhaleem, M .

CLINICAL BIOCHEMISTRY, 2005, 38 (06) :499-503

[2]

BARRENDS WM, 1999, MOL BIOL REPRODUCTIV, P271

[3] Repression of cAMP-induced expression of the mouse P450 17 alpha-hydroxylase/C17-20 lyase gene (Cyp17) by androgens [J].

BurgosTrinidad, M ;

Youngblood, GL ;

Maroto, MR ;

Scheller, A ;

Robins, DM ;

Payne, AH .

MOLECULAR ENDOCRINOLOGY, 1997, 11 (01) :87-96

[4]

Caron C, 2005, PROG MOLEC, V38, P65

[5] ESEfinder: a web resource to identify exonic splicing enhancers [J].

Cartegni, L ;

Wang, JH ;

Zhu, ZW ;

Zhang, MQ ;

Krainer, AR .

NUCLEIC ACIDS RESEARCH, 2003, 31 (13) :3568-3571

[6] A quantitative sucrose gradient analysis of the translational activity of 18 mRNA species in testes from adult mice [J].

Cataldo, L ;

Mastrangelo, MA ;

Kleene, KC .

MOLECULAR HUMAN REPRODUCTION, 1999, 5 (03) :206-213

[7] Infertility with defective spermatogenesis and hypotestosteronemia in male mice lacking the androgen receptor in Sertoli cells [J].

Chang, CS ;

Chen, YT ;

Yeh, SD ;

Xu, QQ ;

Wang, RS ;

Guillou, F ;

Lardy, H ;

Yeh, SY .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (18) :6876-6881

[8] The androgen receptor in spermatogenesis [J].

Collins, LL ;

Lee, HJ ;

Chen, YT ;

Chang, M ;

Hsu, HY ;

Yeh, S ;

Chang, C .

CYTOGENETIC AND GENOME RESEARCH, 2003, 103 (3-4) :299-301

[9] The DEAD-box protein family of RNA helicases [J].

Cordin, O ;

Banroques, J ;

Tanner, NK ;

Linder, P .

GENE, 2006, 367 :17-37

[10] Mouse MAELSTROM: the link between meiotic silencing of unsynapsed chromatin and microRNA pathway? [J].

Costa, Yael ;

Speed, Robert M. ;

Gautier, Philippe ;

Semple, Colin A. ;

Maratou, Klio ;

Turner, James M. A. ;

Cooke, Howard J. .

HUMAN MOLECULAR GENETICS, 2006, 15 (15) :2324-2334

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