Rare occurrence of IgVH gene translocations and restricted IgVH gene repertoire in ocular MALT-type lymphoma

被引：10

作者：

Adam, Patrick ^{[1
]}

Haralambieva, Eugenia ^{[1
]}

Hartmann, Martina ^{[1
]}

Mao, Zhengrong ^{[1
]}

Ott, German ^{[1
]}

Rosenwald, Andreas ^{[1
]}

机构：

[1] Univ Wurzburg, Inst Pathol, Josef Schneider Str 2, D-97080 Wurzburg, Germany

来源：

HAEMATOLOGICA | 2008年 / 93卷 / 02期

关键词：

D O I：

10.3324/haematol.11950

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

FISH studies on 37 ocular MALT-type lymphomas yielded chromosomal translocations affecting MALT1 and BCL10 in 1 case each, no evidence for a break in the FOXP1 locus, and trisomy 3 in 14 out of 34 cases (41%). Three out of 8 cases analyzed used the highly mutated VH3-23 gene and showed ongoing somatic hypermutations.

引用

页码：319 / 320

页数：2

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