Variable frequencies of MALT lymphoma-associated genetic aberrations in MALT lymphomas of different sites

被引：271

作者：

Streubel, B

Simonitsch-Klupp, I

Müllauer, L

Lamprecht, A

Huber, D

Siebert, R

Stolte, M

Trautinger, F

Lukas, J

Püspök, A

Formanek, M

Assanasen, T

Müller-Hermelink, HK

Cerroni, L

Raderer, M

Chott, A

机构：

[1] Med Univ Vienna, Vienna Gen Hosp, Inst Pathol, A-1090 Vienna, Austria

[2] Univ Hosp Schleswig Holstein, Inst Human Genet, Lubeck, Germany

[3] Klinikum Bayreuth, Dept Pathol, Bayreuth, Germany

[4] Med Univ Vienna, Vienna Gen Hosp, Inst Dermatol, Vienna, Austria

[5] Med Univ Vienna, Vienna Gen Hosp, Inst Ophthalmol, Vienna, Austria

[6] Med Univ Vienna, Vienna Gen Hosp, Div Gastroenterol, Vienna, Austria

[7] Med Univ Vienna, Vienna Gen Hosp, Div Otorhinolaryngol, Vienna, Austria

[8] Univ Wurzburg, Inst Pathol, D-8700 Wurzburg, Germany

[9] Med Univ Graz, Inst Dermatol, Graz, Austria

[10] Med Univ Vienna, Vienna Gen Hosp, Div Oncol, Vienna, Austria

来源：

LEUKEMIA | 2004年 / 18卷 / 10期

关键词：

MALT lymphoma; genetics; MALT1; API2; BCL10;

D O I：

10.1038/sj.leu.2403501

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Although several recurrent genetic aberrations are known to occur in MALT lymphoma, no comprehensive study on the most prevalent MALT lymphoma-associated genetic aberrations is available. We therefore screened 252 primary MALT lymphomas for translocations t(11; 18)(q21; q21), t( 14; 18) (q32; q21), and t(1; 14)(p22; q32), and trisomies 3 and 18. The above-listed translocations occurred mutually exclusively and were detected overall in 13.5, 10.8, and 1.6% of the cases; trisomy 3 and/or 18 occurred in 42.1%. The frequency at which the translocations occurred varied markedly with the primary site of disease. The t(11; 18)( q21; q21) was mainly detected in pulmonary and gastric tumors, whereas the t(14; 18)(q32; q21) was most commonly found in lesions of the ocular adnexa/ orbit, skin, and salivary glands. Trisomies 3 and 18 each occurred most frequently in intestinal and salivary gland MALT lymphomas. Our results demonstrate that the three translocations and trisomies 3 and 18 occur at markedly variable frequencies in MALT lymphoma of different sites.

引用

页码：1722 / 1726

页数：5

共 40 条

[1] No evidence of a correlation between BCL10 expression and API2-MALT1 gene rearrangement in ocular adnexal MALT lymphoma [J].