microRNAs: A safeguard against turmoil?

被引:161
作者
Leung, Anthony K. L. [1 ]
Sharp, Phillip A. [1 ]
机构
[1] MIT, Ctr Canc Res, Cambridge, MA 02139 USA
关键词
D O I
10.1016/j.cell.2007.08.010
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Emerging data suggest that microRNAs ( miRNAs) are instrumental in a variety of stress responses in addition to their more recognized role in development. Surprisingly, miRNAs, which normally suppress expression of target transcripts, may become activators of expression during stress. This might be partially explained by new interactions of miRNA/Argonaute complexes with RNA-binding proteins that relocate from different subcellular compartments during stress.
引用
收藏
页码:581 / 585
页数:5
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