The role of p38 MAPK in valproic acid induced microglia apoptosis

被引：55

作者：

Xie, Nanchang ^{[1
,2
]}

Wang, Cui ^{[3
]}

Lin, Youting ^{[1
]}

Li, Hui ^{[2
]}

Chen, Lin ^{[4
]}

Zhang, Tongxia ^{[1
]}

Sun, Yong ^{[5
]}

Zhang, Yi ^{[2
]}

Yin, Deling ^{[2
]}

Chi, Zhaofu ^{[1
]}

机构：

[1] Shandong Univ, Qilu Hosp, Dept Neurol, Jinan 250012, Peoples R China

[2] E Tennessee State Univ, Dept Internal Med, Coll Med, Johnson City, TN 37614 USA

[3] Zhengzhou Univ, Cell Biol Lab, Dept Biol, Zhengzhou 450001, Peoples R China

[4] Shandong Univ, Sch Med, Dept Pharmacol, Jinan 250012, Peoples R China

[5] Peoples Hosp Laiwu City, Dept Gen Surg, Laiwu 271100, Peoples R China

来源：

NEUROSCIENCE LETTERS | 2010年 / 482卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Valproic acid; Microglia; p38; MAPK; Apoptosis; CELLS; NEUROTOXICITY; NEUROGENESIS; MITOCHONDRIA; ACTIVATION; MECHANISMS; DEATH; MODEL; JNK;

D O I：

10.1016/j.neulet.2010.07.004

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Valproic acid (VPA), a widely prescribed drug for seizures and bipolar disorder, induces apoptosis in microglia, but the underlying mechanism by which microglia apoptosis in response to VPA is not yet known. In this study, we found that the mitochondrial pathway played an important role in VPA-induced apoptosis in both BV-2 microglia and mouse primary microglial cells. In addition, VPA increased the level of phospho-p38 mitogen-activated protein kinase (MAPK), but had no effects on phospho-ERK and phospho-JNK MAPKs. Moreover, p38 inhibitor SB203580 strongly inhibited VPA-induced apoptosis and caspase-3 activation. Taken together, our results clearly demonstrated that VPA could induce apoptosis of microglia via p38 MAPK and mitochondrial apoptosis pathway. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

引用

页码：51 / 56

页数：6

共 22 条

[1]

MEKK4 stimulation of p38 and JNK activity is negatively regulated by GSK3β [J].