Pharmacological properties and functional role of a TRP-related ion channel in lobster olfactory receptor neurons

被引：27

作者：

Bobkov, YV

Ache, BW

机构：

[1] Univ Florida, Whitney Lab Marine Biosci, Gainesville, FL 32080 USA

[2] Univ Florida, Ctr Smell & Taste, Dept Zool, Gainesville, FL 32080 USA

[3] Univ Florida, Ctr Smell & Taste, Dept Neurosci, St Augustine, FL 32080 USA

[4] Univ Florida, McKnight Brain Inst, St Augustine, FL 32080 USA

来源：

JOURNAL OF NEUROPHYSIOLOGY | 2005年 / 93卷 / 03期

关键词：

D O I：

10.1152/jn.00990.2004

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Odors activate lobster olfactory receptor neurons (ORNs) through phosphoinositide signaling that appears to target a Na+-gated nonselective cation channel. The Na+-gated channel is a potential member of the growing family of transient receptor potential (TRP) channels. Here, we test the effect of potential antagonists on the channel in cell-free patches from cultured lobster ORNs. We show that the channel is antagonized by H+ and the TRP channel blockers 2-aminoethoxydiphenyl borate, SKF96365, ruthenium red, Al3+, Gd3+, and La3+. We then use this enhanced antagonist profile together with the agonists Na+ and Ca2+ to implicate the channel in signal amplification in the cells.

引用

收藏

页码：1372 / 1380

页数：9

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