Usefulness of S100P in diagnosis of adenocarcinoma of pancreas on fine-needle aspiration biopsy specimens

被引：44

作者：

Deng, Hongbing ^{[1
]}

Shi, Jianhui ^{[1
]}

Wilkerson, Myra ^{[1
]}

Meschter, Steven ^{[1
]}

Dupree, William ^{[1
]}

Lin, Fan ^{[1
]}

机构：

[1] Geisinger Med Ctr, Dept Lab Med, Danville, PA 17822 USA

来源：

AMERICAN JOURNAL OF CLINICAL PATHOLOGY | 2008年 / 129卷 / 01期

关键词：

S100P; pancreas; adenocarcinoma; fine-needle aspiration biopsy;

D O I：

10.1309/5D76NDE81LE8G545

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Even though the cytologic criteria for pancreatic ductal adenocarcinoma (PDA) on fine-needle aspiration biopsy (FNAB) specimens have been well defined, a diagnostic challenge is still present. We immunohistochemically evaluated the diagnostic value of S100P on cell-block and/or smear preparations in 58 cases of FNAB specimens of the pancreas. The 58 cases were divided into 4 groups: 1, 32 cases of PDA; 2, 6 cases with an atypical or "suspicious" diagnosis; 3, 14 cases of benign or reactive ductal epithelium; and 4, 6 cases of endocrine tumor Positive immunoreactivity for S100P was observed in all cases in groups I and 2, whereas only I of 14 cases in group 3 was positive for S100P All cases in group 4 were negative for S100P S100P is a sensitive and specific marker for the detection of PDA on FNAB specimens on cell-block and smear preparations.

引用

页码：81 / 88

页数：8

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