Exploring the common dynamics of homologous proteins. Application to the globin family

被引：64

作者：

Maguid, S ^{[1
]}

Fernandez-Alberti, S ^{[1
]}

Ferrelli, L ^{[1
]}

Echave, J ^{[1
]}

机构：

[1] Univ Nacl Quilmes, Bernal, Argentina

来源：

BIOPHYSICAL JOURNAL | 2005年 / 89卷 / 01期

关键词：

D O I：

10.1529/biophysj.104.053041

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

We present a procedure to explore the global dynamics shared between members of the same protein family. The method allows the comparison of patterns of vibrational motion obtained by Gaussian network model analysis. After the identification of collective coordinates that were conserved during evolution, we quantify the common dynamics within a family. Representative vectors that describe these dynamics are defined using a singular value decomposition approach. As a test case, the globin heme-binding family is considered. The two lowest normal modes are shown to be conserved within this family. Our results encourage the development of models for protein evolution that take into account the conservation of dynamical features.

引用

页码：3 / 13

页数：11

共 62 条

[11] THE 1.9-ANGSTROM STRUCTURE OF DEOXY-BETA(4) HEMOGLOBIN - ANALYSIS OF THE PARTITIONING OF QUATERNARY-ASSOCIATED AND LIGAND-INDUCED CHANGES IN TERTIARY STRUCTURE [J].